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- Table of Contents
PHGDH Antibodies
AND PHGDH ELISA kits, PHGDH Proteins
Many biological assays use antibodies to detect PHGDH, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PHGDH in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PHGDH antibodies...
Designing a Western blot for PHGDH? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PHGDH Western Blot GuideDesigning an IHC experiment for PHGDH? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the PHGDH IHC GuidePHGDH Infographic by Boster Bio
All PHGDH Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # A03355-1
100 μg/vial
Cat # A03355-1
100 μg/vial
PHGDH Overview
Facts about D-3-phosphoglycerate dehydrogenase.
D-3-phosphoglycerate dehydrogenase (PHGDH)
Catalyzes the reversible oxidation of 3-phospho-D- glycerate to 3-phosphonooxypyruvate, the first step of this phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate.
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Gene Information
| Human | |
|---|---|
| Gene Name: | PHGDH |
| Uniprot: | O43175 |
| Entrez: | 26227 |
Family
| Belongs to: |
|---|
| D-isomer specific 2-hydroxyacid dehydrogenase family |
Alternative Names
3,3-phosphoglycerate dehydrogenase; 3PGDH; 3-PGDH; D-3-phosphoglycerate dehydrogenase; EC 1.1.1; EC 1.1.1.95; MGC3017; PDG; PDGH3; PGAD; PGD; PGDH; PHGDH; phosphoglycerate dehydrogenase; SERA
Molecular Weight
Mass (kDA):
56.651 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p12 |
| Sequence: | 1; NC_000001.11 (119711934..119744218) |
Diseases
- Malignant Neoplasms
- Microcephaly
- Cell Transformation, Neoplastic
- Neoplasms
- Nervousness
- Melanoma
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Schizophrenia
- Growth Retardation
- Malnutrition
Pathways
- Cell Proliferation
- Neurogenesis
- Cell Growth
- Pathogenesis
- Glycolysis
- Secretion
- Transport
- Cell Migration
- Brain Development
- Lung Development
- Localization
- Cartilage Development
- Neuroprotection
PTMs
- Phosphorylation
Research Areas
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PHGDH
bosterbio.com/bosterbio-gene-info-cards/PHGDH
References
PMID: 10713460 by Cho H.M., et al. Nucleotide sequence and differential expression of the human 3- phosphoglycerate dehydrogenase gene.
PMID: 11055895 by Klomp L.W.J., et al. Molecular characterization of 3-phosphoglycerate dehydrogenase deficiency -- a neurometabolic disorder associated with reduced L- serine biosynthesis.