PHLDA3 Antibodies

AND PHLDA3 ELISA kits, PHLDA3 Proteins

Many biological assays use antibodies to detect PHLDA3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PHLDA3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PHLDA3 antibodies...

We validate the specificity of these antibodies to PHLDA3 by testing them on tissues known to express PHLDA3 positively and negatively. Browse below to find the PHLDA3 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for PHLDA3? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the PHLDA3 IHC Guide

PHLDA3 Infographic by Boster Bio

All PHLDA3 Products

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Product

Figures

Specificity

Applications

Price

Anti-PHLDA3 Antibody

Western Blot analysis of various cells using PHLDA3 Polyclonal Antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using PHLDA3 Antibody

Human, Mouse, Rat

ELISA, IF, IHC, WB

$380
Cat # A09241
100ul

PHLDA3 (NM_012396) Human Over-expression Lysate

Human

$628
Cat # LS023612
20 µg, 100 µg

PHLDA3 (NM_012396) Human Recombinant Protein

Coomassie blue staining of purified PHLDA3 protein

$1062
Cat # PROTQ9Y5J5
20 µg

PHLDA3 Overview

Facts about Pleckstrin homology-like domain family A member 3.

PHLDA3 3D structure. Source: alphafold

Pleckstrin homology-like domain family A member 3 (PHLDA3)

p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation into the cellular membrane and activation.

Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1.

Gene Information

Human
Gene Name:	PHLDA3
Uniprot:	Q9Y5J5
Entrez:	23612

Family

Belongs to:

PHLDA3 family

Alternative Names

family A, member 2; pleckstrin homology-like domain, family A, member 3; TIH1TDAG51/Ipl homolog 1

Molecular Weight

Mass (kDA):
13.891 kDA

Genomic Context


Human

Location:	1q32.1
Sequence:	1; NC_000001.11 (201464278..201469188, complement)

Tissue Specificity

Widely expressed with lowest expression in liver and spleen.

Subcellular Localizations

Cytoplasm. Membrane; Peripheral membrane protein.

Diseases

Malignant Neoplasms
Neoplasms
Carcinoma
Lung Neoplasms
Embryonal Carcinoma
Malignant Neoplasm Of Breast
Neurodegenerative Disorders
Malignant Neoplasm Of Lung
Neoplasms, Germ Cell And Embryonal
Edema
Tumor Angiogenesis
Hemorrhage

Nervousness
Mammary Neoplasms
Carcinoma, Lobular
Adenocarcinoma
Malignant Neoplasm Of Prostate
Neoplasm Recurrence, Local
Cell Transformation, Neoplastic

Pathways

Cell Cycle
Cell Proliferation
Induction Of Apoptosis
Fertilization
Dna Repair
Dna Methylation
Platelet Activation
Hypersensitivity
Blood Circulation

Methylation
Coagulation
Cell Growth
Angiogenesis

PTMs

Phosphorylation

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PHLDA3

References

PMID: 10594239 by Frank D., et al. A novel pleckstrin homology-related gene family defined by Ipl/Tssc3, TDAG51, and Tih1: tissue-specific expression, chromosomal location, and parental imprinting.

PMID: 15940259 by Kerley-Hamilton J.S., et al. A p53-dominant transcriptional response to cisplatin in testicular germ cell tumor-derived human embryonal carcinoma.