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- Table of Contents
Facts about ATP-dependent DNA helicase PIF1.
Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase.
Human | |
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Gene Name: | PIF1 |
Uniprot: | Q9H611 |
Entrez: | 80119 |
Belongs to: |
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helicase family |
C15orf20; PIF; PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae); PIF1 5-to-3 Prime DNA helicase homolog; PIF1 DNA helicase; PIF1/RRM3 DNA helicase-like protein; RRM3 DNA helicase-like protein
Mass (kDA):
69.799 kDA
Human | |
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Location: | 15q22.31 |
Sequence: | 15; NC_000015.10 (64815632..64827173, complement) |
Weak ubiquitous expression.
Nucleus.; [Isoform 4]: Mitochondrion.
PMID: 16522649 by Zhang D.-H., et al. The human Pif1 helicase, a potential Escherichia coli RecD homologue, inhibits telomerase activity.
PMID: 18835853 by Gu Y., et al. Biochemical analysis of human PIF1 helicase and functions of its N- terminal domain.