GPI mannosyltransferase 3 Antibodies

AND PIGB ELISA kits, GPI mannosyltransferase 3 Proteins

Many biological assays use antibodies to detect GPI mannosyltransferase 3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GPI mannosyltransferase 3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GPI mannosyltransferase 3 antibodies...

We validate the specificity of these antibodies to GPI mannosyltransferase 3 by testing them on tissues known to express PIGB positively and negatively. Browse below to find the PIGB antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PIGB Infographic by Boster Bio

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PIGB Overview

Facts about GPI mannosyltransferase 3.

PIGB 3D structure. Source: alphafold

GPI mannosyltransferase 3 (PIGB)

Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the next alpha-1,2-mannose into Man2-GlcN-acyl-PI during GPI precursor assembly.

Gene Information

Human
Gene Name:	PIGB
Uniprot:	Q92521
Entrez:	9488

Family

Belongs to:

glycosyltransferase 22 family

Alternative Names

EC 2.4.1; EC 2.4.1.-; GPI mannosyltransferase 3; GPI mannosyltransferase III; GPI-MT-III; MGC21236; phosphatidylinositol glycan anchor biosynthesis, class B; phosphatidylinositol glycan, class B; Phosphatidylinositol-glycan biosynthesis class B protein; PIG-B

Molecular Weight

Mass (kDA):
65.056 kDA

Genomic Context


Human

Location:	15q21.3
Sequence:	15; NC_000015.10 (55318939..55355648)

Subcellular Localizations

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Diseases

Hemoglobinuria
Paroxysmal Nocturnal Hemoglobinuria
Thymus Neoplasms
Thymoma
Salmonella Infections

Pathways

Protein Secretion
Virulence
Secretion

PTMs

Gpi Anchoring

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PIGB

References

PMID: 8861954 by Takahashi M., et al. PIG-B, a membrane protein of the endoplasmic reticulum with a large lumenal domain, is involved in transferring the third mannose of the GPI anchor.

PMID: 7907094 by Mohney R.P., et al. Glycoinositol phospholipid anchor-defective K562 mutants with biochemical lesions distinct from those in Thy-1- murine lymphoma mutants.