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- Table of Contents
PINX1 Antibodies
AND PINX1 ELISA kits, PINX1 Proteins
Many biological assays use antibodies to detect PINX1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PINX1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PINX1 antibodies...
Designing a Western blot for PINX1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PINX1 Western Blot GuidePINX1 Infographic by Boster Bio
All PINX1 Products
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PINX1 Overview
Facts about PIN2/TERF1-interacting telomerase inhibitor 1.
PIN2/TERF1-interacting telomerase inhibitor 1 (PINX1)
Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres.
Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor.
Gene Information
| Human | |
|---|---|
| Gene Name: | PINX1 |
| Uniprot: | Q96BK5 |
| Entrez: | 54984 |
Family
| Belongs to: |
|---|
| PINX1 family |
Alternative Names
FLJ20565; hepatocellular carcinoma-related putative tumor suppressor; Liver-related putative tumor suppressor; LPTLPinX1; LPTS67-11-3 protein; MGC8850; PIN2 interacting protein 1; PIN2/TERF1 interacting, telomerase inhibitor 1; PIN2/TERF1-interacting telomerase inhibitor 1; PIN2-interacting protein 1; Pin2-interacting protein X1; Protein 67-11-3; TRF1-interacting protein 1
Molecular Weight
Mass (kDA):
37.035 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8p23.1 |
| Sequence: | 8; NC_000008.11 (10764961..10839899, complement) |
Tissue Specificity
Ubiquitous; expressed at low levels. Not detectable in a number of hepatocarcinoma cell lines.
Subcellular Localizations
Nucleus. Nucleus, nucleolus. Chromosome, telomere. Chromosome, centromere, kinetochore. Localizes in nucleoli, at telomere speckles and to the outer plate of kinetochores. Localization to the kinetochore is mediated by its central region and depends on NDC80 and CENPE.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Telomere Shortening
- Liver Carcinoma
- Stomach Neoplasms
- Cell Transformation, Neoplastic
- Liver Neoplasms
- Malignant Neoplasm Of Stomach
- Mammary Neoplasms
- Leukemia
- Neoplasm Metastasis
Interacting Proteins
- TERF1
Pathways
- Localization
- Telomere Maintenance
- Mitosis
- Cell Growth
- Cell Proliferation
- Senescence
- Cell Cycle
- S Phase
- Rna Interference
- Cellular Senescence
- Aging
- Chromosome Segregation
- Anaphase
PTMs
- Phosphorylation
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PINX1
bosterbio.com/bosterbio-gene-info-cards/PINX1
References
PMID: 11003615 by Liao C., et al. Identification of the gene for a novel liver-related putative tumor suppressor at a high-frequency loss of heterozygosity region of chromosome 8p23 in human hepatocellular carcinoma.
PMID: 11701125 by Zhou X.Z., et al. The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor.