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- Table of Contents
PIP5K1A Antibodies
AND PIP5K1A ELISA kits, PIP5K1A Proteins
Many biological assays use antibodies to detect PIP5K1A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PIP5K1A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PIP5K1A antibodies...
Designing an IHC experiment for PIP5K1A? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the PIP5K1A IHC GuidePIP5K1A Infographic by Boster Bio
All PIP5K1A Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # A07416-3
100 μg/vial
Cat # A07416-3
100 μg/vial
Human
$960
Cat # LS008394
20 µg, 100 µg
Cat # LS008394
20 µg, 100 µg
PIP5K1A Overview
Facts about Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha.
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1A)
Catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another messenger.
The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organization, cell adhesion, migration and phagocytosis.
Gene Information
| Human | |
|---|---|
| Gene Name: | PIP5K1A |
| Uniprot: | Q99755 |
| Entrez: | 8394 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha; EC 2.7.1; EC 2.7.1.68; Phosphatidylinositol-4-phosphate 5-kinase type I alpha; phosphatidylinositol-4-phosphate 5-kinase type-1 alpha; phosphatidylinositol-4-phosphate 5-kinase, type I, alpha; PIP5K1-alpha; PIP5KIalpha; PtdIns(4)P-5-kinase 1 alpha
Molecular Weight
Mass (kDA):
62.633 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q21.3 |
| Sequence: | 1; NC_000001.11 (151197954..151249536) |
Tissue Specificity
Highly expressed in heart, placenta, skeletal muscle, kidney and pancreas. Detected at lower levels in brain, lung and liver.
Subcellular Localizations
Cell membrane. Cytoplasm. Nucleus speckle. Cell projection, ruffle. Cell projection, lamellipodium. Nucleus. Colocalizes with RAC1 at actin-rich membrane ruffles. Localizes to nuclear speckles and associates with TUT1 to regulate polyadenylation of selected mRNAs.
Diseases
- Glioblastoma Multiforme
- Neoplasms
- Glioma
- Glioblastoma
- Chimera Disorder
- Brain Neoplasms
Interacting Proteins
- TUT1
Pathways
- Methylation
- Transport
- Translation
- Cellular Localization
- Cell Cycle
- Mitosis
- Neurogenesis
- Rna Processing
PTMs
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PIP5K1A
bosterbio.com/bosterbio-gene-info-cards/PIP5K1A
References
PMID: 8955136 by Loijens J.C., et al. Type I phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid kinase family.
PMID: 15157668 by Luo B., et al. Diacylglycerol kinase zeta regulates phosphatidylinositol 4-phosphate 5-kinase Ialpha by a novel mechanism.