PKD1L1 Antibodies

AND PKD1L1 ELISA kits, PKD1L1 Proteins

Many biological assays use antibodies to detect PKD1L1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PKD1L1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PKD1L1 antibodies...

We validate the specificity of these antibodies to PKD1L1 by testing them on tissues known to express PKD1L1 positively and negatively. Browse below to find the PKD1L1 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PKD1L1 Infographic by Boster Bio

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PKD1L1 Overview

Facts about Polycystic kidney disease protein 1-like 1.

Polycystic kidney disease protein 1-like 1 (PKD1L1)

Component of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD2L1 in primary cilia and forms a calcium-permeant ciliary channel that modulates sonic hedgehog/SHH signaling and GLI2 transcription.

Doesn't constitute the pore-forming subunit. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD2 in cilia to facilitate flow detection in left/right patterning.

Gene Information

Human
Gene Name:	PKD1L1
Uniprot:	Q8TDX9
Entrez:	168507

Family

Belongs to:

polycystin family

Alternative Names

PC1-like 1 protein; polycystic kidney disease 1 like 1; polycystic kidney disease protein 1-like 1; polycystin-1L1; PRO19563

Molecular Weight

Mass (kDA):
315.435 kDA

Genomic Context


Human

Location:	7p12.3
Sequence:	7; NC_000007.14 (47774603..47958913, complement)

Tissue Specificity

Detected in testis and in fetal and adult heart.

Subcellular Localizations

Cell projection, cilium membrane; Multi-pass membrane protein.

Diseases

Polycystic Kidney Diseases
Kidney Diseases
Polycystic Kidney, Autosomal Dominant
Brain Ischemia
Infarction
Malignant Neoplasm Of Breast
Infertility
Hydrocephalus
Dyskinetic Syndrome
Malignant Neoplasms
Neoplasms
Hemorrhage

Cerebral Infarction
Cerebrovascular Accident
(balanced Rearrangements Or Structural Markers Nec) Or (balanced Translocations)
Situs Inversus
Chromosome Breakage
Mammary Neoplasms
Chimera Disorder

Pathways

Transposition
Localization

PTMs

Glycoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PKD1L1

References

PMID: 11863367 by Yuasa T., et al. The sequence, expression, and chromosomal localization of a novel polycystic kidney disease 1-like gene, PKD1L1, in human.

PMID: 24336289 by DeCaen P.G., et al. Direct recording and molecular identification of the calcium channel of primary cilia.