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- Table of Contents
PLA2G6 Antibodies
AND PLA2G6 ELISA kits, PLA2G6 Proteins
Many biological assays use antibodies to detect PLA2G6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PLA2G6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PLA2G6 antibodies...
Designing a Western blot for PLA2G6? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PLA2G6 Western Blot GuidePLA2G6 Infographic by Boster Bio
All PLA2G6 Products
Product
Figures
Specificity
Applications
Price
Human
$628
Cat # LS008398
20 µg, 100 µg
Cat # LS008398
20 µg, 100 µg
$1249
Cat # PROTO60733
20 µg
Cat # PROTO60733
20 µg
PLA2G6 Overview
Facts about 85/88 kDa calcium-independent phospholipase A2.
85/88 kDa calcium-independent phospholipase A2 (PLA2G6)
Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production.
May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation.
Gene Information
| Human | |
|---|---|
| Gene Name: | PLA2G6 |
| Uniprot: | O60733 |
| Entrez: | 8398 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
calcium-independent phospholipase A2; EC 3.1.1.4; Group VI phospholipase A2; IPLA2; iPLA285 kDa calcium-independent phospholipase A2; IPLA2-VIA; NBIA2A; NBIA2B; PARK14GVI; patatin-like phospholipase domain containing 9; phospholipase A2, group VI (cytosolic, calcium-independent); PNPLA9
Molecular Weight
Mass (kDA):
89.903 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 22q13.1 |
| Sequence: | 22; NC_000022.11 (38111495..38181830, complement) |
Tissue Specificity
Four different transcripts were found to be expressed in a distinct tissue distribution.
Subcellular Localizations
[Isoform LH-iPLA2]: Membrane; Peripheral membrane protein. Recruited to the membrane-enriched pseudopod upon MCP1/CCL2 stimulation in monocytes.; [Isoform SH-iPLA2]: Cytoplasm.
Diseases
- Neuroaxonal Dystrophies
- Nerve Degeneration
- Dystrophy
- Infantile Neuroaxonal Dystrophy
- Neurodegenerative Disorders
- Inflammation
- Parkinson Disease
- Atrophy
- Secondary Parkinson Disease
- Dystonia Disorders
- Malignant Neoplasms
- Hallervorden-spatz Syndrome
Pathways
- Cell Death
- Pathogenesis
- Localization
- Cell Cycle
- Secretion
- Cell Proliferation
- Insulin Secretion
- Cell Growth
- Translation
- Inflammatory Response
- Chemotaxis
- Phagocytosis
- Apoptotic Process
PTMs
- Phosphorylation
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PLA2G6
bosterbio.com/bosterbio-gene-info-cards/PLA2G6
References
PMID: 9417066 by Larsson P.K.A., et al. Multiple splice variants of the human calcium-independent phospholipase A2 and their effect on enzyme activity.
PMID: 10336645 by Larsson Forsell P.K.A., et al. The human calcium-independent phospholipase A2 gene. Multiple enzymes with distinct properties from a single gene.