PLEKHG2 Antibodies

AND PLEKHG2 ELISA kits, PLEKHG2 Proteins

Many biological assays use antibodies to detect PLEKHG2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PLEKHG2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PLEKHG2 antibodies...

We validate the specificity of these antibodies to PLEKHG2 by testing them on tissues known to express PLEKHG2 positively and negatively. Browse below to find the PLEKHG2 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PLEKHG2 Infographic by Boster Bio

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PLEKHG2 Overview

Facts about Pleckstrin homology domain-containing family G member 2.

PLEKHG2 3D structure. Source: alphafold

Pleckstrin homology domain-containing family G member 2 (PLEKHG2)

Might be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42.

Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide- binding protein (G protein) (PubMed:18045877). Involved in the regulation of actin polymerization (PubMed:26573021).

Gene Information

Human
Gene Name:	PLEKHG2
Uniprot:	Q9H7P9
Entrez:	64857

Family

Belongs to:

No superfamily

Alternative Names

ARHGEF42; CLGFLJ38638; common-site lymphoma/leukemia guanine nucleotide exchange factor; DKFZp667J2325; FLJ00018; FLJ22458; PH domain-containing family G member 2; pleckstrin homology domain containing, family G (with RhoGef domain) member 2; pleckstrin homology domain-containing family G member 2

Molecular Weight

Mass (kDA):
147.969 kDA

Genomic Context


Human

Location:	19q13.2
Sequence:	19; NC_000019.10 (39412582..39428415)

Diseases

Osteoarthropathy
Pertussis
Osteoporosis

Pathways

Bioluminescence
Osteoclast Differentiation
Chemotaxis
Lipid Modification

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PLEKHG2

References

PMID: 18045877 by Ueda H., et al. Heterotrimeric G protein betagamma subunits stimulate FLJ00018, a guanine nucleotide exchange factor for Rac1 and Cdc42.

PMID: 26573021 by Edvardson S., et al. Microcephaly-dystonia due to mutated PLEKHG2 with impaired actin polymerization.