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PLK4 Antibodies
AND PLK4 ELISA kits, PLK4 Proteins
Many biological assays use antibodies to detect PLK4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PLK4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PLK4 antibodies...
Designing a Western blot for PLK4? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PLK4 Western Blot GuidePLK4 Infographic by Boster Bio
All PLK4 Products
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PLK4 Overview
Facts about Serine/threonine-protein kinase PLK4.
Serine/threonine-protein kinase PLK4 (PLK4)
Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification during the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase.
Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication indicates a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors.
Gene Information
| Human | |
|---|---|
| Gene Name: | PLK4 |
| Uniprot: | O00444 |
| Entrez: | 10733 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.11.21; PLK-4; polo-like kinase 4 (Drosophila); polo-like kinase 4SAKSTK18serine/threonine kinase 18; Sak; serine/threonine protein kinase SAK; Serine/threonine-protein kinase 18; serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase Sak; Snk akin kinase
Molecular Weight
Mass (kDA):
108.972 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4q28.1 |
| Sequence: | 4; NC_000004.12 (127880893..127899224) |
Subcellular Localizations
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus, nucleolus. Cleavage furrow. Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Associates with centrioles throughout the cell cycle. According to PubMed:16244668, it is not present at cleavage furrows.
Diseases
- Malignant Neoplasms
- Neoplasms
- Aneuploidy
- Cell Transformation, Neoplastic
- Genomic Instability
- Carcinoma
- Liver Carcinoma
- Carcinogenesis
- Malignant Paraganglionic Neoplasm
- Haploinsufficiency
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
Interacting Proteins
- ARR3
- BTRC
- C1orf109
- CEP152
- CEP192
- ECT2
- ELOA
- SFN
- STIL
Pathways
- Cell Cycle
- Mitosis
- Centrosome Duplication
- Cell Division
- Localization
- Cytokinesis
- Interphase
- Cell Proliferation
- Cell Growth
- S Phase
- Proteolysis
- Centriole Replication
- Meiosis
PTMs
- Phosphorylation
- Methylation
Research Areas
- Cell Cycle and Replication
- Core ESC-Like Genes
- Mitotic Regulators
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PLK4
bosterbio.com/bosterbio-gene-info-cards/PLK4
References
PMID: 11489907 by Yamashita Y., et al. Sak serine-threonine kinase acts as an effector of Tec tyrosine kinase.
PMID: 8260651 by Mills G.B., et al. Transmembrane signaling by the interleukin-2 receptor: progress and conundrums.