Phospholipid phosphatase 1 (PLPP1)

Broad-specificity phosphohydrolase which dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system.

Major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling activities of LPA. May control circulating, and possibly also regulate localized, LPA levels caused by platelet activation.