Protein PML (PML)

Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral protection mechanisms. Acts as the scaffold of PML-NBs allowing different proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions.

Isoform PML-4 also: acts as a transcriptional repressor of TBX2 during cellular senescence and the repression is determined by a functional RBL2/E2F4 repressor complex, regulates double-strand fracture repair in gamma- irradiation-induced DNA damage responses via its interaction with WRN, acts as a negative regulator of telomerase by interacting with TERT, also modulates PER2 nuclear localization and cognitive function. Isoform PML-6 inhibits specifically the action of the tetrameric form of PKM.