PNLDC1 Antibodies

AND PNLDC1 ELISA kits, PNLDC1 Proteins

Many biological assays use antibodies to detect PNLDC1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PNLDC1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PNLDC1 antibodies...

We validate the specificity of these antibodies to PNLDC1 by testing them on tissues known to express PNLDC1 positively and negatively. Browse below to find the PNLDC1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PNLDC1 Infographic by Boster Bio

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PNLDC1 (NM_173516) Human Over-expression Lysate

Human

$960
Cat # LS154197
20 µg, 100 µg

PNLDC1 Overview

Facts about Poly(A)-specific ribonuclease PNLDC1.

PNLDC1 3D structure. Source: alphafold

Poly(A)-specific ribonuclease PNLDC1 (PNLDC1)

3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails (PubMed:27515512). Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also utilized to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development (PubMed:27515512).

May act as a regulator of multipotency in embryonic stem cells (By similarity). .

Gene Information

Human
Gene Name:	PNLDC1
Uniprot:	Q8NA58
Entrez:	154197

Family

Belongs to:

CAF1 family

Alternative Names

dJ195P10.2; FLJ40240; MGC138451; poly(A)-specific ribonuclease (PARN)-like domain containing 1; poly(A)-specific ribonuclease PARN-like domain-containing protein 1

Molecular Weight

Mass (kDA):
60.124 kDA

Genomic Context


Human

Location:	6q25.3
Sequence:	6; NC_000006.12 (159799422..159820704)

Subcellular Localizations

Endoplasmic reticulum membrane; Single-pass membrane protein. Localizes mainly in the endoplasmic reticulum (PubMed:27515512).

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PNLDC1

References

PMID: 27515512 by Anastasakis D., et al. Mammalian PNLDC1 is a novel poly(A) specific exonuclease with discrete expression during early development.