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- Table of Contents
Liprin-alpha-1 Antibodies
AND PPFIA1 ELISA kits, Liprin-alpha-1 Proteins
Many biological assays use antibodies to detect Liprin-alpha-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Liprin-alpha-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Liprin-alpha-1 antibodies...
Designing an IHC experiment for Liprin-alpha-1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the PPFIA1 IHC GuidePPFIA1 Infographic by Boster Bio
All PPFIA1 Products
Product
Figures
Specificity
Applications
Price
Human
$960
Cat # LS008500
20 µg, 100 µg
Cat # LS008500
20 µg, 100 µg
PPFIA1 Overview
Facts about Liprin-alpha-1.
Liprin-alpha-1 (PPFIA1)
May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.
.
Gene Information
| Human | |
|---|---|
| Gene Name: | PPFIA1 |
| Uniprot: | Q13136 |
| Entrez: | 8500 |
Family
| Belongs to: |
|---|
| liprin family |
Alternative Names
FLJ42630; FLJ43474; LAR-interacting protein 1; LIP.1; LIP-1; LIP1FLJ41337; LIPRIN; Liprin-alpha1; liprin-alpha-1; MGC26800; Protein tyrosine phosphatase receptor type f polypeptide-interacting proteinalpha-1; protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interactingprotein (liprin), alpha 1; PTPRF-interacting protein alpha-1
Molecular Weight
Mass (kDA):
135.779 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q13.3 |
| Sequence: | 11; NC_000011.10 (70270687..70384405) |
Tissue Specificity
Ubiquitous.
Subcellular Localizations
Cytoplasm. Colocalizes with PTPRF at the ends of focal adhesions most proximal to the cell nucleus.
Diseases
- Tissue Adhesions
- Neoplasms
- Carcinoma
- Malignant Squamous Cell Neoplasm
- Malignant Neoplasms
- Head And Neck Carcinoma
- Neoplasm Metastasis
- Nervousness
- Cell Invasion
- Malignant Neoplasm Of Breast
- Tumor Angiogenesis
- Mammary Neoplasms
- Laryngeal Neoplasm
Interacting Proteins
- CCNH
- DTNB
- FAM161A
- Gria2
- Grip1
- MBIP
- PPP2R5D
- TXLNA
Pathways
- Localization
- Cell Motility
- Axon Guidance
- Rna Interference
- Cell Adhesion
- Cell Migration
- Mammary Gland Development
- Cell Proliferation
- Gland Development
- Dendrite Development
- Synaptic Transmission
- Angiogenesis
- Pathogenesis
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PPFIA1
bosterbio.com/bosterbio-gene-info-cards/PPFIA1
References
PMID: 7796809 by Serra-Pages C., et al. The LAR transmembrane protein tyrosine phosphatase and a coiled-coil LAR-interacting protein co-localize at focal adhesions.
PMID: 8524829 by Pulido R., et al. The LAR/PTP delta/PTP sigma subfamily of transmembrane protein- tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1.