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Periphilin-1 Antibodies
AND PPHLN1 ELISA kits, Periphilin-1 Proteins
Many biological assays use antibodies to detect Periphilin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Periphilin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Periphilin-1 antibodies...
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PPHLN1 Infographic by Boster Bio
All PPHLN1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IF, ICC, WB
$370
Cat # A06996-3
100 μg/vial
Cat # A06996-3
100 μg/vial
PPHLN1 Overview
Facts about Periphilin-1.
Periphilin-1 (PPHLN1)
Component of the HUSH complicated, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci full of H3K9me3 and is probably required to maintain transcriptional silencing by encouraging recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3.
In the HUSH complex, contributes to the upkeep of the complex at chromatin (PubMed:26022416). Acts as a transcriptional corepressor and modulates the cell cycle, probably through the HUSH complicated (PubMed:15474462, PubMed:17963697).
Gene Information
| Human | |
|---|---|
| Gene Name: | PPHLN1 |
| Uniprot: | Q8NEY8 |
| Entrez: | 51535 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
Gastric cancer antigen Ga50; HSPC232; MGC48786; periphilin 1; periphilin-1
Molecular Weight
Mass (kDA):
52.737 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q12 |
| Sequence: | 12; NC_000012.12 (42326126..42448621) |
Tissue Specificity
Ubiquitous.
Subcellular Localizations
Nucleus. Cytoplasm. Chromosome. In undifferentiated keratinocytes expressed in speckle-type nuclear granules and at the nuclear membrane, but in the differentiated keratinocytes colocalized with periplakin at the cell periphery and at cell-cell junctions (PubMed:12853457). Localizes to chromatin (PubMed:26022416).
Diseases
- Congenital Nonbullous Ichthyosiform Erythroderma
- Neurodegenerative Disorders
- Ichthyoses
- Congenital Ichthyosis
- Parkinson Disease
Interacting Proteins
- CCDC57
- MTUS2
- TSGA10
Pathways
- Dna Replication
- Cornification
- Cell Cycle
- Pathogenesis
- Localization
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PPHLN1
bosterbio.com/bosterbio-gene-info-cards/PPHLN1
References
PMID: 12087473 by Line A., et al. Serological identification and expression analysis of gastric cancer- associated genes.
PMID: 12853457 by Kazerounian S., et al. Characterization of periphilin, a widespread, highly insoluble nuclear protein and potential constituent of the keratinocyte cornified envelope.