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- Table of Contents
Protein phosphatase 1D Antibodies
AND PPM1D ELISA kits, Protein phosphatase 1D Proteins
Many biological assays use antibodies to detect Protein phosphatase 1D, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein phosphatase 1D in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein phosphatase 1D antibodies...
Designing an IHC experiment for Protein phosphatase 1D? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the PPM1D IHC GuidePPM1D Infographic by Boster Bio
All PPM1D Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A01577-3
100 μg/vial
Cat # A01577-3
100 μg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A01576-1
100 μg/vial
Cat # A01576-1
100 μg/vial
Human, Mouse, Rat
ELISA, IF, IHC-P, WB
$481
Cat # A01576
0.1 mg
Cat # A01576
0.1 mg
PPM1D Overview
Facts about Protein phosphatase 1D.
Protein phosphatase 1D (PPM1D)
Involved in the negative regulation of p53 expression (PubMed:23242139). Required for the aid of p53-dependent checkpoint mediated cell cycle arrest.
Binds to and dephosphorylates'Ser-15' of TP53 and'Ser-345' of CHEK1 which leads to the functional inactivation of these proteins (PubMed:15870257, PubMed:16311512). Mediates MAPK14 dephosphorylation and inactivation (PubMed:21283629).
Gene Information
| Human | |
|---|---|
| Gene Name: | PPM1D |
| Uniprot: | O15297 |
| Entrez: | 8493 |
Family
| Belongs to: |
|---|
| PP2C family |
Alternative Names
EC 3.1.3.16; p53-induced protein phosphatase 1; PP2C-delta; PPM1D; protein phosphatase 1D magnesium-dependent, delta isoform; protein phosphatase 1D; protein phosphatase 2C delta isoform; Protein phosphatase 2C isoform delta; Protein phosphatase magnesium-dependent 1 delta; protein phosphatase, Mg2+/Mn2+ dependent, 1D; wild-type p53-induced phosphatase 1; Wip1; WIP1protein phosphatase Wip1
Molecular Weight
Mass (kDA):
66.675 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q23.2 |
| Sequence: | 17; NC_000017.11 (60600187..60666280) |
Tissue Specificity
Expressed in fetal and adult brain. Also detected in fetal liver and skeletal muscle, but not in their adult counterparts.
Subcellular Localizations
Nucleus. Cytoplasm, cytosol.
Diseases
- Malignant Neoplasms
- Neoplasms
- Mammary Neoplasms
- Malignant Neoplasm Of Breast
- Cell Transformation, Neoplastic
- Carcinoma
- Malignant Paraganglionic Neoplasm
- Ataxia Telangiectasia
- Adenocarcinoma
- Genotoxic Stress
- Ductal Breast Carcinoma
- Ataxia
Interacting Proteins
- H2AFX
- MDM2
- RUNX2
Pathways
- Cell Cycle
- Dna Repair
- Cell Death
- Rna Interference
- Cell Cycle Checkpoint
- Cell Cycle Arrest
- Cell Proliferation
- Localization
- Cell Growth
- Mrna Stabilization
- Dna Damage Checkpoint
- Pathogenesis
- Gene Silencing
PTMs
- Phosphorylation
- Dephosphorylation
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PPM1D
bosterbio.com/bosterbio-gene-info-cards/PPM1D
References
PMID: 9177166 by Fiscella M., et al. Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner.
PMID: 15870257 by Lu X., et al. PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints.
11 Publications of Boster Protein phosphatase 1D Antibodies & ELISA Kits
- PubMed ID: PMID:26722422, Wnt/β-catenin pathway is required for epithelial to mesenchymal transition in C...
- PubMed ID: PMID:26617787, RAC1 overexpression promotes the proliferation, migration and epithelial-mesench...
- PubMed ID: 10.3892/etm.2013.1431, Expression of N‑cadherin proteins in myocardial hypertrophy in rats
- PubMed ID: 10.3390/ijms222010930, TMEM16A, a Homoharringtonine Receptor, as a Potential Endogenic Target for Lung ...
- PubMed ID: 10.3389/fphar.2021.643489, Inhibition of TMEM16A by Natural Product Silibinin: Potential Lead Compounds for...
- PubMed ID: 10.1139/bcb-2017-0074, The CXCL12–CXCR4 axis promotes migration, invasiveness, and EMT in human papil...
- PubMed ID: 10.1080/09168451.2017.1356216, Kallikrein-related peptidase 4 contributes to the tumor metastasis of oral squam...
- PubMed ID: 10.1002/path.4443, MiR‐506 inhibits multiple targets in the epithelial‐to‐mesenchymal transit...
- PubMed ID: 32519176, Piao HY,Guo S,Wang Y,Zhang J.Exosome-transmitted lncRNA PCGEM1 promotes invasive...
- PubMed ID: 33069797, Shi R,Liu L,Wang F,He Y,Niu Y,Wang C,Zhang X,Zhang X,Zhang H,Chen M,Wang Y.Downr...
- PubMed ID: 32158357, Yang Z,Zhang J,Lu D,Sun Y, Zhao X,Wang X,Zhou W,He Q,Jiang Z.Hsa_circ_0137008 su...
*More publications can be found for each product on its corresponding product page