PPP3CB Antibodies

AND PPP3CB ELISA kits, PPP3CB Proteins

Many biological assays use antibodies to detect PPP3CB, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PPP3CB in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PPP3CB antibodies...

We validate the specificity of these antibodies to PPP3CB by testing them on tissues known to express PPP3CB positively and negatively. Browse below to find the PPP3CB antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for PPP3CB? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the PPP3CB IHC Guide

PPP3CB Infographic by Boster Bio

All PPP3CB Products

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Applications

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Anti-PPP3CB Antibody Picoband®

Western blot analysis of PPP3CB using anti-PPP3CB antibody (A07303-1)

IHC analysis of PPP3CB using anti-PPP3CB antibody (A07303-1)

Human, Monkey, Mouse, Rat

ELISA, Flow Cytometry, IHC, WB

$370
Cat # A07303-1
100 µg/vial

PPP3CB (NM_021132) Human Over-expression Lysate

PPP3CB Human Over-expression Lysates NM_001142353

Human

$628
Cat # LS005532
20 µg, 100 µg

PPP3CB Overview

Facts about Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform.

PPP3CB 3D structure. Source: alphafold

Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (PPP3CB)

Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:19154138, PubMed:26794871). Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138).

Dephosphorylates and inactivates transcription factor ELK1 (PubMed:19154138). Dephosphorylates DARPP32 (PubMed:19154138).

Gene Information

Human
Gene Name:	PPP3CB
Uniprot:	P16298
Entrez:	5532

Family

Belongs to:

PPP phosphatase family

Alternative Names

Calmodulin-dependent calcineurin A subunit beta isoform; CALNA2protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform(calcineurin A beta); CAM-PRP catalytic subunit; CNA2catalytic subunit, beta isoform; EC 3.1.3.16; protein phosphatase 2B, catalytic subunit, beta isoform; protein phosphatase 3, catalytic subunit, beta isozyme; protein phosphatase from PCR fragment H32; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

Molecular Weight

Mass (kDA):
59.024 kDA

Genomic Context


Human

Location:	10q22.2
Sequence:	10; NC_000010.11 (73436428..73496024, complement)

Subcellular Localizations

Cytoplasm.

Diseases

Hypertrophy
Cardiac Hypertrophy
Fibrosis
Malignant Neoplasms
Hypertrophic Cardiomyopathy
Cardiomyopathies
Neoplasm Metastasis
Malnutrition
Squamous Cell Carcinoma Of Skin
Glioma
Airway Obstruction
Carcinogenesis

Carcinoma
Metastatic Malignant Neoplasm To The Pancreas
Carcinoma, Pancreatic Ductal
Neoplasms
Asthma
Pancreatic Neoplasm
Aplastic Anemia

Interacting Proteins

IRF2

Pathways

Pathogenesis
Localization
Senescence
Swimming
Reverse Transcription
Regulation Of Gene Expression

Intracellular Signal Transduction

PTMs

Dephosphorylation

Phosphorylation

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PPP3CB

References

PMID: 2556704 by Guerini D., et al. Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain.

PMID: 1848109 by McPartlin A.E., et al. Identification of a third alternatively spliced cDNA encoding the catalytic subunit of protein phosphatase 2B beta.