Polyglutamine-binding protein 1 (PQBP1)

Intrinsically disordered protein that serves as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron growth (PubMed:10198427, PubMed:10332029, PubMed:12062018, PubMed:20410308, PubMed:23512658). Interacts with splicing-related factors via the intrinsically disordered region and modulates alternative splicing of goal pre-mRNA species (PubMed:10332029, PubMed:12062018, PubMed:23512658, PubMed:20410308).

May suppress the capacity of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent way. Can activate transcription directly or via association with the transcription machinery (PubMed:10198427).