Pramel7 Antibodies

AND Pramel7 ELISA kits, Pramel7 Proteins

Many biological assays use antibodies to detect Pramel7, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Pramel7 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Pramel7 antibodies...

We validate the specificity of these antibodies to Pramel7 by testing them on tissues known to express Pramel7 positively and negatively. Browse below to find the Pramel7 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Pramel7 Infographic by Boster Bio

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Pramel7 Overview

Facts about Preferentially expressed antigen in melanoma-like protein 7.

Pramel7 3D structure. Source: alphafold

Preferentially expressed antigen in melanoma-like protein 7 (Pramel7)

Promotes care and self-renewal of pluripotent embryonic stem cells (ESCs), downstream of LIF/STAT3 (PubMed:21425410). Maintains the pluripotency state of ESCs by repressing DNA methylation through the regulation of UHRF1 stability.

Mediates the proteasomal degradation of UHRF1. Is required for the establishment of the blastocyst (PubMed:28604677).

Gene Information

Mouse
Gene Name:	Pramel7
Uniprot:	Q810Y8
Entrez:	347712

Family

Belongs to:

PRAME family

Alternative Names

Preferentially expressed antigen in melanoma-like protein 7

Molecular Weight

Mass (kDA):
55.834 kDA

Genomic Context


Mouse

Location:	2\|2 D
Sequence:	2;

Tissue Specificity

Seems to be specific to pluripotent tissues in the early embryo. Not detected in somatic tissues.

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Pramel7

References

PMID: 12620990 by Bortvin A., et al. Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.

PMID: 21425410 by Casanova E.A., et al. Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.