Prolyl endopeptidase-like Antibodies

AND PREPL ELISA kits, Prolyl endopeptidase-like Proteins

Many biological assays use antibodies to detect Prolyl endopeptidase-like, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Prolyl endopeptidase-like in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Prolyl endopeptidase-like antibodies...

We validate the specificity of these antibodies to Prolyl endopeptidase-like by testing them on tissues known to express PREPL positively and negatively. Browse below to find the PREPL antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PREPL Infographic by Boster Bio

All PREPL Products

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Applications

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Anti-Prolyl endopeptidase-like PREPL Antibody

Western blot analysis of extracts of various cell lines, using PREPL antibody at 1:3000 dilution

Immunofluorescence analysis of C6 cells using PREPL Polyclonal Antibody at dilution of 1:100

Immunofluorescence analysis of L929 cells using PREPL Polyclonal Antibody at dilution of 1:100

Human, Mouse, Rat

IF, ICC, WB

$405
Cat # A08771
100ul

Anti-PREPL Rabbit Monoclonal Antibody

Western blot analysis of PREPL expression in (1) MCF7 cell lysate; (2) Raw264

Immunoprecipitate (IP) analysis using the Antibody at 1:50 dilution

Human, Mouse, Rat

Flow Cytometry, IP, IF, ICC, WB

$370
Cat # M08771
100 μl/vial

Anti-PREPL Rabbit Monoclonal Antibody

Western blot analysis of PREPL expression in (1) MCF7 cell lysate; (2) C6 cell lysate

Human, Mouse, Rat

IP, IF, IHC, ICC, WB

$370
Cat # M08771-1
100 μl/vial

PREPL (NM_006036) Human Over-expression Lysate

PREPL Human Over-expression Lysates NM_001042385

Human

$960
Cat # LS009581
20 µg, 100 µg

PREPL Overview

Facts about Prolyl endopeptidase-like.

PREPL 3D structure. Source: alphafold

Prolyl endopeptidase-like (PREPL)

Probable serine peptidase whose exact substrate specificity remains unclear. Does not cleave peptides after a arginine or lysine residue.

May play a role in the regulation of synaptic vesiscle exocytosis (PubMed:24610330). .

Gene Information

Human
Gene Name:	PREPL
Uniprot:	Q4J6C6
Entrez:	9581

Family

Belongs to:

peptidase S9A family

Alternative Names

EC 3.4.21; EC 3.4.21.-; EC 3.4.21.83; KIAA0436FLJ16627; prolyl endopeptidase-like; Prolylendopeptidase-like; putative prolyl oligopeptidase

Molecular Weight

Mass (kDA):
83.927 kDA

Genomic Context


Human

Location:	2p21
Sequence:	2; NC_000002.12 (44317607..44361862, complement)

Tissue Specificity

Widely expressed. Expressed at higher level in brain, skeletal muscle, heart and kidney. Expressed at the endplates in the neuromuscular junction (PubMed:24610330).

Subcellular Localizations

Cytoplasm, cytosol. Golgi apparatus, trans-Golgi network. Cytoplasm, cytoskeleton. Golgi apparatus. Nucleus. Co-localizes with AP-1 in the trans-Golgi network (By similarity). Co-localizes with MAP2 and ACTB on the cytoskeleton (By similarity). Co-localizes with STX6 and GOSR2 at the Golgi apparatus (By similarity).

Diseases

Cystinuria
Muscle Hypotonia
Neonatal Hypotonia
Failure To Thrive
Growth Retardation
Somatotropin Deficiency
Congenital Anomaly Of Face
Hyperphagia
Isolated Cystinuria
Cytochrome-c Oxidase Deficiency
Congenital Disorders

Kidney Calculi
Moderate Mental Retardation
Hypokinesia
Patient Dependence On
Nervousness

Pathways

Localization

PTMs

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PREPL

References

PMID: 15913950 by Parvari R., et al. The 2p21 deletion syndrome: characterization of the transcription content.

PMID: 16143824 by Szeltner Z., et al. The PREPL A protein, a new member of the prolyl oligopeptidase family, lacking catalytic activity.