This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
PRKG1 Antibodies
AND PRKG1 ELISA kits, PRKG1 Proteins
Many biological assays use antibodies to detect PRKG1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PRKG1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PRKG1 antibodies...
Designing a Western blot for PRKG1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PRKG1 Western Blot GuideDesigning an IHC experiment for PRKG1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the PRKG1 IHC GuidePRKG1 Infographic by Boster Bio
All PRKG1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A01708-3
100 μg/vial
Cat # A01708-3
100 μg/vial
PRKG1 Overview
Facts about cGMP-dependent protein kinase 1.
cGMP-dependent protein kinase 1 (PRKG1)
Serine/threonine protein kinase that acts as crucial mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins.
Numerous protein targets for PRKG1 phosphorylation are implicated in regulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 modulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of this NO-signaling pathway, and other processes involved in a number of facets of the CNS such as axon guidance, hippocampal and cerebellar learning, circadian rhythm and nociception.
Gene Information
| Human | |
|---|---|
| Gene Name: | PRKG1 |
| Uniprot: | Q13976 |
| Entrez: | 5592 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
AAT8; cGK 1; cGK; cGK1; cGKI; cGKI-alpha; cGKI-BETA; cGMP-dependent protein kinase I; DKFZp686K042; EC 2.7.11; EC 2.7.11.12; FLJ36117; PKG; PKG1; PRKG1B; PRKG1BMGC71944; PRKGR1A; PRKGR1B; PRKGR1BcGMP-dependent, regulatory, type I, beta; protein kinase cGMP-dependent 1; protein kinase, cGMP-dependent, type I
Molecular Weight
Mass (kDA):
76.364 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q11.23-q21.1 |
| Sequence: | 10; NC_000010.11 (50990888..52298350) |
Tissue Specificity
Primarily expressed in lung and placenta.
Subcellular Localizations
Cytoplasm. Colocalized with TRPC7 in the plasma membrane.
Diseases
- Hypertensive Disease
- Nervousness
- Observation Of Neuromuscular Block
- Malignant Neoplasms
- Hypertrophy
- Cardiovascular Diseases
- Cardiac Hypertrophy
- Pain
- Hypoxia
- Neoplasms
- Pathologic Vasoconstriction
- Erectile Dysfunction
Interacting Proteins
- BMPR2
- FAM124A
- LMO2
- PDE5A
- ZNF646
Pathways
- Secretion
- Vasodilation
- Localization
- Cell Proliferation
- Transport
- Pathogenesis
- Relaxation Of Vascular Smooth Muscle
- Reverse Transcription
- Cell Death
- Platelet Activation
- Neutrophil Activation
- Aging
- Regulation Of Gene Expression
PTMs
- Phosphorylation
- Dephosphorylation
- Cleavage
- Oxidation
Research Areas
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PRKG1
bosterbio.com/bosterbio-gene-info-cards/PRKG1
References
PMID: 2792381 by Sandberg M., et al. Molecular cloning and predicted full-length amino acid sequence of the type I beta isozyme of cGMP-dependent protein kinase from human placenta. Tissue distribution and developmental changes in rat.
PMID: 8613202 by Tamura N., et al. cDNA cloning and gene expression of human type Ialpha cGMP-dependent protein kinase.