This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Pre-mRNA-processing-splicing factor 8.
Functions as scaffold that rankings spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site.
| Human | |
|---|---|
| Gene Name: | PRPF8 |
| Uniprot: | Q6P2Q9 |
| Entrez: | 10594 |

| Belongs to: |
|---|
| No superfamily |

apoptosis-regulated protein 1; apoptosis-regulated protein 2; p220; precursor mRNA processing protein; pre-mRNA-processing-splicing factor 8; PRP8 homolog; PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae); PRP8 pre-mRNA processing factor 8 homolog (yeast); Prp8; PRP8,220 kDa U5 snRNP-specific protein; PRPC8HPRP8; RP13; Splicing factor Prp8; U5 snRNP-specific protein (220 kD), ortholog of S. cerevisiae Prp8p
Mass (kDA):
273.6 kDA

| Human | |
|---|---|
| Location: | 17p13.3 |
| Sequence: | 17; NC_000017.11 (1650629..1684880, complement) |
Widely expressed.
Nucleus. Nucleus speckle.






PMID: 10411133 by Luo H.R., et al. The human Prp8 protein is a component of both U2- and U12-dependent spliceosomes.
PMID: 2532307 by Anderson G.J., et al. Conservation between yeast and man of a protein associated with U5 small nuclear ribonucleoprotein.