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- Table of Contents
Myeloblastin Antibodies
AND PRTN3 ELISA kits, Myeloblastin Proteins
Many biological assays use antibodies to detect Myeloblastin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Myeloblastin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Myeloblastin antibodies...
Designing an IHC experiment for Myeloblastin? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the PRTN3 IHC GuidePRTN3 Infographic by Boster Bio
All PRTN3 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$750
Cat # EK2034
96 wells/kit, with removable strips.
Cat # EK2034
96 wells/kit, with removable strips.
Human
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A03863-3
100 µg/vial
Cat # A03863-3
100 µg/vial
PRTN3 Overview
Facts about Myeloblastin.
Myeloblastin (PRTN3)
Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:3198760, PubMed:2033050, PubMed:28240246). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed:23202369).
May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279). .
Gene Information
| Human | |
|---|---|
| Gene Name: | PRTN3 |
| Uniprot: | P24158 |
| Entrez: | 5657 |
Family
| Belongs to: |
|---|
| peptidase S1 family |
Alternative Names
ACPA; AGP7; AGP7PR3; azurophil granule protein 7; C-ANCA; EC 3.4.21; EC 3.4.21.76; Leukocyte proteinase 3; MBN; MBT; Myeloblastin; Neutrophil proteinase 4; NP4; NP-4; P29C-ANCA antigen; PR-3CANCA; Proteinase 3; PRTN3; serine proteinase, neutrophil; Wegener autoantigen; Wegener granulomatosis autoantigen
Molecular Weight
Mass (kDA):
27.807 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19p13.3 |
| Sequence: | 19; NC_000019.10 (840965..848175) |
Tissue Specificity
Expressed in polymorphonuclear leukocytes (at protein level) (PubMed:2033050, PubMed:7897245, PubMed:3198760). Expressed in neutrophils (at protein level) (PubMed:28240246, PubMed:18462208, PubMed:21193407, PubMed:22266279, PubMed:17244676). Expressed in differentiating neutrophils (PubMed:18462208).
Subcellular Localizations
Cytoplasmic granule. Secreted. Cell membrane; Peripheral membrane protein; Extracellular side. Membrane raft; Peripheral membrane protein; Extracellular side. Localizes predominantly to azurophil granules (primary secretory granules) in neutrophils (PubMed:2033050, PubMed:3198760, PubMed:7897245, PubMed:18462208). Secreted upon neutrophil stimulation by TNF-alpha, lipopolysaccharide (LPS), fMLP and CXCL8/IL8 or during neutrophil transmigration (PubMed:22266279, PubMed:28240246). Following secretion tethered to the cell membrane by CD177 (PubMed:18462208, PubMed:22266279).
Diseases
- Wegener Granulomatosis
- Leukemia
- Autoimmune Reaction
- Vasculitis
- Microscopic Polyangiitis
- Autoimmune Diseases
- Malignant Neoplasm Of Breast
- Lung Diseases
- Leukocyte Adhesion Deficiency
- Churg-strauss Syndrome
- Leukemia, Myelocytic, Acute
- Lung Diseases, Obstructive
Pathways
- Pathogenesis
- Localization
- Myeloid Cell Differentiation
- Cell Differentiation
- Immune Response
- Chromatin Organization
- Respiratory Burst
- Interphase
PTMs
- Disulfide bond
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PRTN3
bosterbio.com/bosterbio-gene-info-cards/PRTN3
References
PMID: 1681549 by Labbaye C., et al. Wegener autoantigen and myeloblastin are encoded by a single mRNA.
PMID: 1518849 by Zimmer M., et al. Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter.