Protein prune homolog 2 Antibodies

AND PRUNE2 ELISA kits, Protein prune homolog 2 Proteins

Many biological assays use antibodies to detect Protein prune homolog 2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein prune homolog 2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein prune homolog 2 antibodies...

We validate the specificity of these antibodies to Protein prune homolog 2 by testing them on tissues known to express PRUNE2 positively and negatively. Browse below to find the PRUNE2 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PRUNE2 Infographic by Boster Bio

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Prune homolog 2 (PRUNE2) (NM_138818) Human Over-expression Lysate

Human

$628
Cat # LS158471
20 µg, 100 µg

PRUNE2 Overview

Facts about Protein prune homolog 2.

Protein prune homolog 2 (PRUNE2)

May play an essential role in regulating differentiation, survival and aggressiveness of the tumor cells. .

Gene Information

Human
Gene Name:	PRUNE2
Uniprot:	Q8WUY3
Entrez:	158471

Family

Belongs to:

PPase class C family

Alternative Names

A214N16.3; bA214N16.3; BCH motif-containing molecule at the carboxyl terminal region 1; BMCC1FLJ50060; BNIP2 motif containing molecule at the carboxyl terminal region 1; BNIP2 motif-containing molecule at the C-terminal region 1; BNIPXLFLJ59118; C9orf65; chromosome 9 open reading frame 65; DKFZp762K117; KIAA0367FLJ54876; protein prune homolog 2; prune homolog 2 (Drosophila); RP11-58J3.2

Molecular Weight

Mass (kDA):
340.635 kDA

Genomic Context


Human

Location:	9q21.2
Sequence:	9; NC_000009.12 (76611376..76906220, complement)

Tissue Specificity

A high level of expression seen in the nervous system (brain, cerebellum and spinal cord) as well as adrenal gland. Expressed at high levels in noneuroblastoma, rhabdomyosarcoma, melanoma and some osteosarcoma cell lines, whereas at only low levels in cancer cell lines of liver, breast, thyroid and colon. Expression is significantly higher in favorable tumors than aggressive ones.

Subcellular Localizations

Cytoplasm.

Diseases

Neoplasms
Malignant Neoplasm Of Prostate
Malignant Neoplasms
Metaplastic Cell Transformation
Neuroblastoma
Leiomyosarcoma
Prostatic Neoplasms
Nervousness
Alzheimer's Disease
Neoplasm Metastasis
Aneurysm
Cell Transformation, Neoplastic

Prostatic Hyperplasia
Gastrointestinal Stromal Tumors
Pathological Dilatation
Malignant Paraganglionic Neoplasm
Atrophy
Tissue Adhesions
Stromal Neoplasm

Pathways

Pathogenesis
Localization
Cell Adhesion
Programmed Cell Death
Cell Death
Regulation Of Cytoskeleton

PTMs

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PRUNE2

References

PMID: 16288218 by Machida T., et al. Increased expression of proapoptotic BMCC1, a novel gene with the BNIP2 and Cdc42GAP homology (BCH) domain, is associated with favorable prognosis in human neuroblastomas.

PMID: 19760627 by Salagierski M., et al. Differential expression of PCA3 and its overlapping PRUNE2 transcript in prostate cancer.