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- Table of Contents
PSMD3 Antibodies
AND PSMD3 ELISA kits, PSMD3 Proteins
Many biological assays use antibodies to detect PSMD3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PSMD3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PSMD3 antibodies...
Designing an IHC experiment for PSMD3? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the PSMD3 IHC GuidePSMD3 Infographic by Boster Bio
All PSMD3 Products
Product
Figures
Specificity
Applications
Price
PSMD3 Overview
Facts about 26S proteasome non-ATPase regulatory subunit 3.
26S proteasome non-ATPase regulatory subunit 3 (PSMD3)
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required.
Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. .
Gene Information
| Human | |
|---|---|
| Gene Name: | PSMD3 |
| Uniprot: | O43242 |
| Entrez: | 5709 |
Family
| Belongs to: |
|---|
| proteasome subunit S3 family |
Alternative Names
26S proteasome regulatory subunit RPN3; 26S proteasome regulatory subunit S3; P58; proteasome (prosome, macropain) 26S subunit, non-ATPase, 3; Proteasome subunit p58; Rpn3; S3, 26S proteasome non-ATPase regulatory subunit 3; tissue specific transplantation antigen 2; TSTA2
Molecular Weight
Mass (kDA):
60.978 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q21.1 |
| Sequence: | 17; NC_000017.11 (39980807..39997959) |
Diseases
- Asthma
- Neoplasms
- Sezary Syndrome
- Crohn Disease
- Lymphoma, T-cell, Cutaneous
- Lymphoma
- Cytogenetic Abnormality
Interacting Proteins
- CEP44
- PLCG2
- PRPF3
- SEM1
- ZBTB43
Pathways
- Pathogenesis
- Secretion
- Lymphocyte Activation
PTMs
- Isopeptide bond
Research Areas
- Neuroscience
- Ubiquitin Proteasome Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PSMD3
bosterbio.com/bosterbio-gene-info-cards/PSMD3
References
PMID: 9017604 by Kominami K., et al. Yeast counterparts of subunits S5a and p58 (S3) of the human 26S proteasome are encoded by two multicopy suppressors of nin1-1.
PMID: 1317798 by Kanayama H.O., et al. Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms.