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- Table of Contents
PSME3 Antibodies
AND PSME3 ELISA kits, PSME3 Proteins
Many biological assays use antibodies to detect PSME3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PSME3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PSME3 antibodies...
Designing an IHC experiment for PSME3? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the PSME3 IHC GuidePSME3 Infographic by Boster Bio
All PSME3 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, IP, IF, IHC, ICC, WB
$370
Cat # A04375-1
100 μg/vial
Cat # A04375-1
100 μg/vial
SDS-PAGE
$250
Cat # PROTP61289
Starting from 10ug
Cat # PROTP61289
Starting from 10ug
PSME3 Overview
Facts about Proteasome activator complex subunit 3.
Proteasome activator complex subunit 3 (PSME3)
Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits.
Facilitates the MDM2-p53/TP53 interaction that promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation.
Gene Information
| Human | |
|---|---|
| Gene Name: | PSME3 |
| Uniprot: | P61289 |
| Entrez: | 10197 |
Family
| Belongs to: |
|---|
| PA28 family |
Alternative Names
11S regulator complex gamma subunit; 11S regulator complex subunit gamma; Activator of multicatalytic protease subunit 3; Ki antigen; Ki; PA28 Activator gamma Subunit; PA28g; PA28gamma; PA28-gamma; PA28GKi nuclear autoantigen; proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki); Proteasome activator 28 subunit gamma; proteasome activator 28-gamma; proteasome activator complex subunit 3; PSME3; REG gamma; REG-GAMMA
Molecular Weight
Mass (kDA):
29.506 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q21.31 |
| Sequence: | 17; NC_000017.11 (42833397..42843760) |
Subcellular Localizations
Nucleus. Cytoplasm. Localizes to the cytoplasm during mitosis following nuclear envelope breakdown at this distinct stage of the cell cycle which allows its interaction with MAP3K3 kinase.
Diseases
- Neoplasms
- Malignant Neoplasms
- Tissue Adhesions
- Diabetes Mellitus
- Intestinal Diseases
- Insulin Resistance
- Diabetes Mellitus, Non-insulin-dependent
- Metabolic Syndrome X
- Colorectal Neoplasms
Interacting Proteins
- ATN1
- BBS2
- COIL
- EAF1
- EAF2
- FBXO7
- MDM2
- NCOA3
- PFDN5
- PRKAB2
Pathways
- Cell Cycle
- Proteolysis
- Localization
- Dna Damage Checkpoint
- Cognition
- Catabolic Process
PTMs
- Phosphorylation
Research Areas
- Core ESC-Like Genes
- Immune System Diseases
- Immunology
- Neuroscience
- Stem Cell Markers
- Ubiquitin Proteasome Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PSME3
bosterbio.com/bosterbio-gene-info-cards/PSME3
References
PMID: 1968796 by Nikaido T., et al. Cloning and nucleotide sequence of cDNA for Ki antigen, a highly conserved nuclear protein detected with sera from patients with systemic lupus erythematosus.
PMID: 7951316 by Albertsen H.M., et al. A physical map and candidate genes in the BRCA1 region on chromosome 17q12-21.