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- Table of Contents
PTPRO Antibodies
AND PTPRO ELISA kits, PTPRO Proteins
Many biological assays use antibodies to detect PTPRO, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PTPRO in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PTPRO antibodies...
Designing an IHC experiment for PTPRO? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the PTPRO IHC GuidePTPRO Infographic by Boster Bio
All PTPRO Products
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PTPRO Overview
Facts about Receptor-type tyrosine-protein phosphatase O.
Receptor-type tyrosine-protein phosphatase O (PTPRO)
Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function (By similarity).
.
Gene Information
| Human | |
|---|---|
| Gene Name: | PTPRO |
| Uniprot: | Q16827 |
| Entrez: | 5800 |
Family
| Belongs to: |
|---|
| protein-tyrosine phosphatase family |
Alternative Names
EC 3.1.3.48; GLEPP1PTPROt; Glomerular epithelial protein 1; phosphotyrosine phosphatase U2; protein tyrosine phosphatase PTP-U2; Protein tyrosine phosphatase U2; protein tyrosine phosphatase, receptor type, O; PTPase U2; PTP-oc; PTP-U2glomerular epithelial protein-1; PTPU2osteoclastic transmembrane protein-tyrosine phosphatase; receptor-type protein tyrosine phosphatase O; receptor-type tyrosine-protein phosphatase O; R-PTP-O
Molecular Weight
Mass (kDA):
138.344 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12p12.3|12p13-p12 |
| Sequence: | 12; NC_000012.12 (15322334..15598331) |
Tissue Specificity
Glomerulus of kidney. Also detected in brain, lung and placenta.
Subcellular Localizations
Membrane; Single-pass type I membrane protein.
Diseases
- Neoplasms
- Posttransfusion Purpura
- Malignant Neoplasms
- Proteinuria Of Undiagnosed Cause
- Kidney Diseases
- Renal Glomerular Disease
- Glomerulosclerosis (disorder)
- Nervousness
- Focal Glomerulosclerosis
- Leukemia
- Nephrotic Syndrome
- Segmental Glomerulosclerosis
- Cell Transformation, Neoplastic
Interacting Proteins
- ERBB2
- MET
- TEK
Pathways
- Methylation
- Axon Guidance
- Cell Proliferation
- Localization
- Demethylation
- Osteoclast Differentiation
- Gene Silencing
- Proteolysis
- Dna Methylation
- Glomerular Filtration
- Axonogenesis
- S Phase
- Dedifferentiation
PTMs
- Phosphorylation
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PTPRO
bosterbio.com/bosterbio-gene-info-cards/PTPRO
References
PMID: 7753550 by Seimiya H., et al. Cloning, expression and chromosomal localization of a novel gene for protein tyrosine phosphatase (PTP-U2) induced by various differentiation-inducing agents.
PMID: 7665166 by Wiggins R.C., et al. Molecular cloning of cDNAs encoding human GLEPP1, a membrane protein tyrosine phosphatase: characterization of the GLEPP1 protein distribution in human kidney and assignment of the GLEPP1 gene to human chromosome 12p12-p13.