PYCR1 Antibodies

AND PYCR1 ELISA kits, PYCR1 Proteins

Many biological assays use antibodies to detect PYCR1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PYCR1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PYCR1 antibodies...

We validate the specificity of these antibodies to PYCR1 by testing them on tissues known to express PYCR1 positively and negatively. Browse below to find the PYCR1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for PYCR1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the PYCR1 Western Blot Guide

Designing an IHC experiment for PYCR1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the PYCR1 IHC Guide

PYCR1 Infographic by Boster Bio

All PYCR1 Products

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Product

Figures

Specificity

Applications

Price

Anti-PYCR1 Antibody Picoband®

Western blot analysis of PYCR1 using anti-PYCR1 antibody (A06018-1)

IHC analysis of PYCR1 using anti-PYCR1 antibody (A06018-1)

Human

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A06018-1
100 µg/vial

PYCR1 (NM_006907) Human Over-expression Lysate

PYCR1 Human Over-expression Lysates NM_006907

Human

$628
Cat # LS005831
20 µg, 100 µg

PYCR1 (NM_006907) Human Recombinant Protein

Coomassie blue staining of purified PYCR1 protein

$1249
Cat # PROTP32322
20 µg

PYCR1 Overview

Facts about Pyrroline-5-carboxylate reductase 1, mitochondrial.

PYCR1 3D structure. Source: alphafold

Pyrroline-5-carboxylate reductase 1, mitochondrial (PYCR1)

Housekeeping enzyme that catalyzes the final step in proline biosynthesis. Can use both NAD and NADP, but has greater affinity for NAD.

Involved in the cellular response to oxidative stress. .

Gene Information

Human
Gene Name:	PYCR1
Uniprot:	P32322
Entrez:	5831

Family

Belongs to:

pyrroline-5-carboxylate reductase family

Alternative Names

ARCL2B; EC 1.5.1.2; mitochondrial pyrroline-5-carboxylate reductase 1; P5C reductase 1; P5C; P5CR 1; P5CR; PIG45; PP222; PRO3; proliferation-inducing protein 45; PYCR; pyrroline-5-carboxylate reductase 1; pyrroline-5-carboxylate reductase 1, mitochondrial

Molecular Weight

Mass (kDA):
33.361 kDA

Genomic Context


Human

Location:	17q25.3
Sequence:	17; NC_000017.11 (81932384..81937328, complement)

Subcellular Localizations

Mitochondrion.

Diseases

Cutis Laxa
Malignant Neoplasms
Fetal Growth Retardation
Neoplasms
Adenocarcinoma
Developmental Delay (disorder)
Growth Retardation
Adenoma
De Barsy Syndrome
Premature Aging Syndrome
Carcinoma
Dwarfism

Prostatic Neoplasms
Dermatologic Disorders
Inborn Errors Of Metabolism
Malignant Neoplasm Of Prostate
Osteopenia
Melanoma
Proline Dehydrogenase Deficiency

Interacting Proteins

PARK7

Pathways

Aging
Glycosylation
Pathogenesis
Cell Adhesion
Translation
Cell Cycle
Biological Regulation
Proteolysis
Cell Growth

Membrane Fusion
Rna Interference
Localization

PTMs

Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PYCR1

References

PMID: 1730675 by Dougherty K.M., et al. Cloning human pyrroline-5-carboxylate reductase cDNA by complementation in Saccharomyces cerevisiae.

PMID: 19648921 by Reversade B., et al. Mutations in PYCR1 cause cutis laxa with progeroid features.