PYHIN1 Antibodies

AND PYHIN1 ELISA kits, PYHIN1 Proteins

Many biological assays use antibodies to detect PYHIN1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PYHIN1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PYHIN1 antibodies...

We validate the specificity of these antibodies to PYHIN1 by testing them on tissues known to express PYHIN1 positively and negatively. Browse below to find the PYHIN1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PYHIN1 Infographic by Boster Bio

All PYHIN1 Products

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PYHIN1 (NM_152501) Human Over-expression Lysate

PYHIN1 Human Over-expression Lysates NM_152501

Human

$960
Cat # LS149628
20 µg, 100 µg

Anti-PYHIN1 Antibody Picoband®

Western blot analysis of PYHIN1 using anti-PYHIN1 antibody (A10377-1)

IHC analysis of PYHIN1 using anti-PYHIN1 antibody (A10377-1)

IF analysis of PYHIN1 using anti-PYHIN1 antibody (A10377-1) and anti-Tubulin Alpha antibody (M03989-3)

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A10377-1
100 μg/vial

PYHIN1 Overview

Facts about Pyrin and HIN domain-containing protein 1.

PYHIN1 3D structure. Source: alphafold

Pyrin and HIN domain-containing protein 1 (PYHIN1)

Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which contributes to p53/TP53 stabilization.

Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enriches maspin expression, and interrupts invasive activity of cancer cells. .

Gene Information

Human
Gene Name:	PYHIN1
Uniprot:	Q6K0P9
Entrez:	149628

Family

Belongs to:

HIN-200 family

Alternative Names

IFIXMGC23885; Interferon-inducible protein X; pyrin and HIN domain family, member 1; pyrin and HIN domain-containing protein 1; RP11-520H16.1

Molecular Weight

Mass (kDA):
55.065 kDA

Genomic Context


Human

Location:	1q23.1
Sequence:	1; NC_000001.11 (158931547..158990909)

Tissue Specificity

Expressed in spleen, lymph node and peripheral blood leukocytes, and at lower levels in thymus, bone marrow and fetal liver. Down-regulated in breast tumors.

Subcellular Localizations

[Isoform 1]: Nucleus, nucleoplasm.; [Isoform 3]: Nucleus, nucleoplasm.; [Isoform 5]: Nucleus. Nucleus speckle.

Diseases

Malignant Neoplasm Of Breast
Malignant Neoplasms
Neoplasms
Mammary Neoplasms
Cell Invasion
Autoimmunity
Cell Transformation, Neoplastic
Neoplasm Metastasis
Innate Immune Response

Asthma
Lupus Erythematosus, Systemic
Tissue Damage

Pathways

Localization
Innate Immune Response
Immune Response
Cell Growth
Pathogenesis

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PYHIN1

References

PMID: 15122330 by Ding Y., et al. Antitumor activity of IFIX, a novel interferon-inducible HIN-200 gene, in breast cancer.

PMID: 16479015 by Ding Y., et al. Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.