Pagr1a Antibodies

AND Pagr1a ELISA kits, Pagr1a Proteins

Many biological assays use antibodies to detect Pagr1a, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Pagr1a in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Pagr1a antibodies...

We validate the specificity of these antibodies to Pagr1a by testing them on tissues known to express Pagr1a positively and negatively. Browse below to find the Pagr1a antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Pagr1a Infographic by Boster Bio

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Pagr1a Overview

Facts about PAXIP1-associated glutamate-rich protein 1A.

Pagr1a 3D structure. Source: alphafold

PAXIP1-associated glutamate-rich protein 1A (Pagr1a)

Its association with the histone methyltransferase MLL2/MLL3 complex is indicating a role in epigenetic transcriptional activation. Nevertheless, in affiliation with PAXIP1/PTIP is proposed to work at least in part independently of the MLL2/MLL3 complex.

Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex (PubMed:19124460). However, its role in DNA damage was contested (PubMed:26744420).

Gene Information

Mouse
Gene Name:	Pagr1a
Uniprot:	Q99L02
Entrez:	67278

Family

Belongs to:

No superfamily

Alternative Names

PAXIP1-associated glutamate-rich protein 1A

Molecular Weight

Mass (kDA):
27.723 kDA

Genomic Context


Mouse

Location:	7\|7 F3
Sequence:	7;

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Pagr1a

References

PMID: 19124460 by Gong Z., et al. Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage.

PMID: 24633704 by Kumar A., et al. Loss of function of mouse Pax-Interacting Protein 1-associated glutamate rich protein 1a (Pagr1a) leads to reduced Bmp2 expression and defects in chorion and amnion development.