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- Table of Contents
Facts about PIH1 domain-containing protein 1.
Mediates interaction of TELO2 using the R2TP complex which is vital for the stability of MTOR and SMG1 (PubMed:20864032). Positively regulates the assembly and activity of the mTORC1 complex (PubMed:24036451).
| Human | |
|---|---|
| Gene Name: | PIH1D1 |
| Uniprot: | Q9NWS0 |
| Entrez: | 55011 |

| Belongs to: |
|---|
| PIH1 family |

NOP17FLJ20643; Nucleolar protein 17 homolog; PIH1 domain containing 1; PIH1 domain-containing protein 1
Mass (kDA):
32.363 kDA

| Human | |
|---|---|
| Location: | 19q13.33 |
| Sequence: | 19; NC_000019.10 (49446298..49452392, complement) |
Expressed at low levels in normal mammary epithelial cells (at protein level) (PubMed:24036451). Highest expression in lung, leukocyte and placenta. Expressed at lower levels in brain, prostate, colon, heart, small intestine, liver, ovary, pancreas, skeletal muscle, spleen, testis and thymus (PubMed:21078300).
Nucleus.





PMID: 17636026 by McKeegan K.S., et al. A dynamic scaffold of pre-snoRNP factors facilitates human box C/D snoRNP assembly.
PMID: 21078300 by Inoue M., et al. PIH1D1, a subunit of R2TP complex, inhibits doxorubicin-induced apoptosis.