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PPP4R2 Antibodies
AND PPP4R2 ELISA kits, PPP4R2 Proteins
Many biological assays use antibodies to detect PPP4R2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PPP4R2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PPP4R2 antibodies...
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PPP4R2 Infographic by Boster Bio
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PPP4R2 Overview
Facts about Serine/threonine-protein phosphatase 4 regulatory subunit 2.
Serine/threonine-protein phosphatase 4 regulatory subunit 2 (PPP4R2)
Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the action of PPP4C at centrosomal microtubule organizing centers.
Its interaction with the SMN complex contributes to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair.
Gene Information
| Human | |
|---|---|
| Gene Name: | PPP4R2 |
| Uniprot: | Q9NY27 |
| Entrez: | 151987 |
Family
| Belongs to: |
|---|
| PPP4R2 family |
Alternative Names
MGC131930; PP4R2; protein phosphatase 4, regulatory subunit 2; serine/threonine-protein phosphatase 4 regulatory subunit 2
Molecular Weight
Mass (kDA):
46.898 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3p13 |
| Sequence: | 3; NC_000003.12 (72996743..73069201) |
Tissue Specificity
Widely expressed.
Subcellular Localizations
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Ionizing radiation induces relocalization to nuclear foci and colocalization with RPA2.
Diseases
- Adrenal Hyperplasia
- Congenital Abnormality
- Developmental Delay (disorder)
- Muscular Atrophy
- Atrophy
- Chromosome Inversion
- Loss Of Chromosome 3
- Developmental Disabilities
- Congenital Adrenal Hyperplasia
- Chronic Active Hepatitis
Interacting Proteins
- PPP4C
Pathways
- Cell Differentiation
- Localization
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PPP4R2
bosterbio.com/bosterbio-gene-info-cards/PPP4R2
References
PMID: 10769191 by Hastie C.J., et al. A novel 50 kDa protein forms complexes with protein phosphatase 4 and is located at centrosomal microtubule organizing centres.
PMID: 12668731 by Carnegie G.K., et al. Protein phosphatase 4 interacts with the survival of motor neurons complex and enhances the temporal localisation of snRNPs.