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- Table of Contents
RAB13 Antibodies
AND RAB13 ELISA kits, RAB13 Proteins
Many biological assays use antibodies to detect RAB13, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RAB13 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RAB13 antibodies...
Designing a Western blot for RAB13? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the RAB13 Western Blot GuideRAB13 Infographic by Boster Bio
All RAB13 Products
Product
Figures
Specificity
Applications
Price
Human, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A04339
100 μg/vial
Cat # A04339
100 μg/vial
RAB13 Overview
Facts about Ras-related protein Rab-13.
Ras-related protein Rab-13 (RAB13)
The small GTPases Rab are crucial regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an energetic GTP-bound form that is able to recruit to membranes distinct sets of downstream effectors directly responsible for vesicle formation, motion, tethering and fusion.
That Rab is involved in endocytic recycling and modulates the transfer to the plasma membrane of transmembrane proteins such as the tight junction protein OCLN/occludin. Thereby, it modulates the assembly and the activity of tight junctions.
Gene Information
| Human | |
|---|---|
| Gene Name: | RAB13 |
| Uniprot: | P51153 |
| Entrez: | 5872 |
Family
| Belongs to: |
|---|
| small GTPase superfamily |
Alternative Names
Cell growth-inhibiting gene 4 protein; growth-inhibiting gene 4 protein; Rab13; RAB13, member RAS oncogene family; RAS-associated protein RAB13; ras-related protein Rab-13
Molecular Weight
Mass (kDA):
22.774 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q21.3 |
| Sequence: | 1; NC_000001.11 (153981605..153990644, complement) |
Tissue Specificity
Detected in several types of epithelia, including intestine, kidney, liver and in endothelial cells.
Subcellular Localizations
Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Cell junction, tight junction. Golgi apparatus, trans-Golgi network membrane. Recycling endosome membrane. Cell projection, lamellipodium. Tight junctions or associated with vesicles scattered throughout the cytoplasm in cells lacking tight junctions (PubMed:8294494). Relocalizes to the leading edge of lamellipodia in migrating endothelial cells (By similarity).
Diseases
- Tissue Adhesions
- Stomatitis
- Vesicular Stomatitis
- Tumor Angiogenesis
- Malignant Neoplasms
- Neoplasms
- Cell Invasion
- Tuberculosis, Pulmonary
- Cholangiocarcinoma
- Spinal Cord Injuries
- Inflammatory Bowel Diseases
- Trauma, Nervous System
Interacting Proteins
- Leprotl1
- Micall2
- PDE6D
Pathways
- Transport
- Localization
- Endocytic Recycling
- Tight Junction Assembly
- Endocytosis
- Regeneration
- Cell Motility
- Cell Adhesion
- Immune Response
- Spermatogenesis
- Cell Cycle
- Intracellular Transport
- Prenylation
PTMs
- Prenylation
- Geranylgeranylation
- Phosphorylation
- Farnesylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RAB13
bosterbio.com/bosterbio-gene-info-cards/RAB13
References
PMID: 8294494 by Zahraoui A., et al. A small rab GTPase is distributed in cytoplasmic vesicles in non polarized cells but colocalizes with the tight junction marker ZO-1 in polarized epithelial cells.
PMID: 8375503 by Joberty G., et al. Isoprenylation of Rab proteins possessing a C-terminal CaaX motif.