Ras-related protein Rab-13 (RAB13)

The small GTPases Rab are crucial regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an energetic GTP-bound form that is able to recruit to membranes distinct sets of downstream effectors directly responsible for vesicle formation, motion, tethering and fusion.

That Rab is involved in endocytic recycling and modulates the transfer to the plasma membrane of transmembrane proteins such as the tight junction protein OCLN/occludin. Thereby, it modulates the assembly and the activity of tight junctions.