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RAB38 Antibodies
AND RAB38 ELISA kits, RAB38 Proteins
Many biological assays use antibodies to detect RAB38, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RAB38 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RAB38 antibodies...
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RAB38 Infographic by Boster Bio
All RAB38 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, WB
$335
Cat # A05500
100ul
Cat # A05500
100ul
RAB38 Overview
Facts about Ras-related protein Rab-38.
Ras-related protein Rab-38 (RAB38)
May be involved in melanosomal transportation and docking. Involved in the proper sorting of TYRP1.
Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which likely is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7 (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.
Gene Information
| Human | |
|---|---|
| Gene Name: | RAB38 |
| Uniprot: | P57729 |
| Entrez: | 23682 |
Family
| Belongs to: |
|---|
| small GTPase superfamily |
Alternative Names
Melanoma antigen NY-MEL-1; NY-MEL-1; RAB38, member RAS oncogene family; Rab-related GTP-binding protein; ras-related protein Rab-38; rrGTPbp
Molecular Weight
Mass (kDA):
23.712 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q14.2 |
| Sequence: | 11; NC_000011.10 (87809490..88175504, complement) |
Tissue Specificity
Expressed in melanocytes.
Subcellular Localizations
Cell membrane; Lipid-anchor; Cytoplasmic side. Melanosome. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Melanosome membrane. Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). The BLOC-3 complex, a heterodimer of HPS1 and HPS4 promotes its membrane localization (PubMed:23084991).
Diseases
- Hermanski-pudlak Syndrome
- Albinism, Oculocutaneous
- Albinism
- Melanoma
- Malignant Neoplasms
- Neoplasms
- Hemorrhage
- Malignant Paraganglionic Neoplasm
- Hereditary Diseases
- Bleeding Tendency
- Lung Diseases
- Hypopigmentation Disorder
Pathways
- Transport
- Pigmentation
- Vesicle Transport
- Localization
- Surfactant Homeostasis
- Melanocyte Differentiation
- Pathogenesis
- Secretion
- Osteoclast Differentiation
- Eye Pigmentation
- Phagosome Maturation
- Immune Response
- Proteolysis
PTMs
- Farnesylation
- Prenylation
- Cleavage
Research Areas
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RAB38
bosterbio.com/bosterbio-gene-info-cards/RAB38
References
PMID: 10910072 by Jaeger D., et al. Serological cloning of a melanocyte rab guanosine 5'-triphosphate- binding protein and a chromosome condensation protein from a melanoma complementary DNA library.
PMID: 12643545 by Basrur V., et al. Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.