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- Table of Contents
Facts about Double-strand-break repair protein rad21-like protein 1.
Replaces RAD21 at premeiotic S phase (during first stages of prophase I), while RAD21 reappears in later stages of prophase I. involved with synaptonemal complex assembly, synapsis initiation and crossover recombination between homologous chromosomes during prophase I (By similarity).
Human | |
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Gene Name: | RAD21L1 |
Uniprot: | Q9H4I0 |
Entrez: | 642636 |
Belongs to: |
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rad21 family |
dJ545L17.2; RAD21L; RAD21L1 RAD21-like 1 (S. pombe)
Mass (kDA):
63.324 kDA
Human | |
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Location: | 20p13 |
Sequence: | 20; NC_000020.11 (1226040..1255876) |
Nucleus. Chromosome. In meiotic chromosomes, localized along axial elements in early meiosis: detectable on the axial elements in leptotene, and stays on the axial/lateral elements until mid pachytene. It then disappears and is replaced with RAD21. Compared to REC8, has mutually exclusive loading sites on the chromosomes: REC8 and RAD21L form distinct cohesin-enriched domains along the axial elements.
PMID: 11780052 by Deloukas P., et al. The DNA sequence and comparative analysis of human chromosome 20.