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- Table of Contents
RAPGEF3 Antibodies
AND RAPGEF3 ELISA kits, RAPGEF3 Proteins
Many biological assays use antibodies to detect RAPGEF3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RAPGEF3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RAPGEF3 antibodies...
Designing a Western blot for RAPGEF3? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the RAPGEF3 Western Blot GuideRAPGEF3 Infographic by Boster Bio
All RAPGEF3 Products
Product
Figures
Specificity
Applications
Price
Anti-Epac1/RAPGEF3 Antibody Picoband®
1 Citations
Human, Monkey, Mouse
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A02483-3
100 μg/vial
Cat # A02483-3
100 μg/vial
Anti-Epac1 Rabbit Monoclonal Antibody
1 Citations
Human, Mouse, Rat
IP, IF, IHC, ICC, WB
$370
Cat # M02483
100 μl
Cat # M02483
100 μl
Human, Monkey, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A02483-2
100 μg/vial
Cat # A02483-2
100 μg/vial
RAPGEF3 Overview
Facts about Rap guanine nucleotide exchange factor 3.
Rap guanine nucleotide exchange factor 3 (RAPGEF3)
Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is triggered by binding cAMP. Through simultaneous binding of PDE3B into RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis.
Plays a role in the modulation of this cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho- mediated signaling. Required for the actin rearrangement at cell- cell junctions, such as stress fibers and junctional actin.
Gene Information
| Human | |
|---|---|
| Gene Name: | RAPGEF3 |
| Uniprot: | O95398 |
| Entrez: | 10411 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
9330170P05Rik; bcm910; cAMP-GEFI; cAMP-regulated guanine nucleotide exchange factor I; CGEF1; EPAC 1; EPAC1; EPACRAP guanine-nucleotide-exchange factor (GEF) 3; Exchange factor directly activated by cAMP 1; Exchange protein directly activated by cAMP 1; HSU79275; MGC21410; Rap guanine nucleotide exchange factor (GEF) 3; rap guanine nucleotide exchange factor 3; Rap1 guanine-nucleotide-exchange factor directly activated by cAMP
Molecular Weight
Mass (kDA):
103.751 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q13.11 |
| Sequence: | 12; NC_000012.12 (47734363..47758880, complement) |
Tissue Specificity
Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney.
Subcellular Localizations
Endomembrane system.
Diseases
- Tissue Adhesions
- Malignant Neoplasms
- Neoplasms
- Inflammation
- Melanoma
- Hypertrophy
- Carcinoma
- Neoplasm Metastasis
- Tumor Angiogenesis
- Pathologic Neovascularization
- Malignant Paraganglionic Neoplasm
- Mycoplasma Pneumonia
- Asthma
Interacting Proteins
- PDE3B
Pathways
- Cell Adhesion
- Secretion
- Cell Proliferation
- Insulin Secretion
- Cell Migration
- Exocytosis
- Pathogenesis
- Chemotaxis
- Localization
- Transport
- Cell Cycle
- Angiogenesis
- Response To Camp
PTMs
- Phosphorylation
- Methylation
- Sumoylation
- Phosphorothioation
Research Areas
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RAPGEF3
bosterbio.com/bosterbio-gene-info-cards/RAPGEF3
References
PMID: 9856955 by Kawasaki H., et al. A family of cAMP-binding proteins that directly activate rap1.
PMID: 9853756 by de Rooij J., et al. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP.