Rap guanine nucleotide exchange factor 3 (RAPGEF3)

Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is triggered by binding cAMP. Through simultaneous binding of PDE3B into RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis.

Plays a role in the modulation of this cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho- mediated signaling. Required for the actin rearrangement at cell- cell junctions, such as stress fibers and junctional actin.