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- Table of Contents
Facts about Rap guanine nucleotide exchange factor 3.
Plays a role in the modulation of this cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho- mediated signaling. Required for the actin rearrangement at cell- cell junctions, such as stress fibers and junctional actin.
Human | |
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Gene Name: | RAPGEF3 |
Uniprot: | O95398 |
Entrez: | 10411 |
Belongs to: |
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No superfamily |
9330170P05Rik; bcm910; cAMP-GEFI; cAMP-regulated guanine nucleotide exchange factor I; CGEF1; EPAC 1; EPAC1; EPACRAP guanine-nucleotide-exchange factor (GEF) 3; Exchange factor directly activated by cAMP 1; Exchange protein directly activated by cAMP 1; HSU79275; MGC21410; Rap guanine nucleotide exchange factor (GEF) 3; rap guanine nucleotide exchange factor 3; Rap1 guanine-nucleotide-exchange factor directly activated by cAMP
Mass (kDA):
103.751 kDA
Human | |
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Location: | 12q13.11 |
Sequence: | 12; NC_000012.12 (47734363..47758880, complement) |
Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney.
Endomembrane system.
If you're interested in the history of Steven Boster, then this article is for you. We'll explore His work and family. You'll also learn more about the RAPGEF3 marker and its uses. You'll be amazed by the range of applications this new marker can have! In this Boster Bio, we'll explore Steven Boster's background, his family, and more.
If you are looking for Steve Boster's background, you've come to the right place. Public records about Steve Boster will give you information about his home address, cell phone numbers, email addresses, and known relatives. By searching public records, you can narrow down the results by state, age, or even keyword. If you are looking for Steve Boster's past addresses, you can narrow down your search by selecting a city.
The last time we heard from Steve Boster was on June 26, 2022. He passed away from COVID-19, an inoperable blood cancer. He was 61 years old when he passed away. During his lifetime, Boster was a manager in the retail industry. He was also a member of Concordia Hall in Staunton, VA. In addition to his mother, Steve was also survived by his 2 daughters, Natosha Peck and Crystal Boster, 6 grandchildren, 4 Brothers, Jack Boster, and Sandra Blanton. Besides his wife, Steve Boster also had a daughter-in-law, Lisa Milton, and many nieces and nephews.
Recent studies have revealed that RAPGEF3 regulates the expression of the cancer stem cell marker JNK. Activation of RAPGEF3 by PDE3B, which is an inhibitor of PI3K gamma complex, also inhibits JNK. This study has important implications for the development of anticancer therapies. Although the exact mechanisms by which RAPGEF3 regulates JNK are not fully understood, it seems that the kinase is required for the regulation of the gene.
PMID: 9856955 by Kawasaki H., et al. A family of cAMP-binding proteins that directly activate rap1.
PMID: 9853756 by de Rooij J., et al. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP.