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RASGRP1 Antibodies
AND RASGRP1 ELISA kits, RASGRP1 Proteins
Many biological assays use antibodies to detect RASGRP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RASGRP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RASGRP1 antibodies...
Designing a Western blot for RASGRP1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the RASGRP1 Western Blot GuideRASGRP1 Infographic by Boster Bio
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RASGRP1 Overview
Facts about RAS guanyl-releasing protein 1.
RAS guanyl-releasing protein 1 (RASGRP1)
Functions as a calcium- and diacylglycerol (DAG)- regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP (PubMed:15899849, PubMed:23908768). Activates the Erk/MAP kinase cascade (PubMed:15899849).
Regulates T-cell/B-cell growth, homeostasis and differentiation by coupling T-lymphocyte/B- lymphocyte antigen receptors to Ras (PubMed:10807788, PubMed:12839994). Regulates NK cell cytotoxicity and ITAM- dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (PubMed:19933860).
Gene Information
| Human | |
|---|---|
| Gene Name: | RASGRP1 |
| Uniprot: | O95267 |
| Entrez: | 10125 |
Family
| Belongs to: |
|---|
| RASGRP family |
Alternative Names
RAS guanyl-releasing protein 1; CALDAG-GEFI; CALDAG-GEFII; hRasGRP1; RAS guanyl releasing protein 1 (calcium and DAG-regulated); RASGRP
Molecular Weight
Mass (kDA):
90.402 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 15q14 |
| Sequence: | 15; NC_000015.10 (38488097..38564814, complement) |
Tissue Specificity
Expressed in brain with higher expression in cerebellum, cerebral cortex and amygdala. Expressed in the hematopoietic system. Expressed in T-cells (at protein level). Expressed in NK cells (at protein level) (PubMed:19933860).
Subcellular Localizations
Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Found both in the cytosol and associated with membranes. Relocalization to the cell membrane upon activation is F-actin-dependent. Translocates to the Golgi in response to phorbol ester or nerve growth factor. Localizes to somata and dendrites but not to axons of hippocampal pyramidal cells (By similarity).
Diseases
- Neoplasms
- Malignant Neoplasms
- Autoimmunity
- Leukemia
- Lymphoma
- Leukemia, Myelocytic, Acute
- Tissue Adhesions
- Cell Transformation, Neoplastic
- Myeloid Leukemia
- Carcinogenesis
- Skin Neoplasms
- Lupus Erythematosus, Systemic
Pathways
- Localization
- Cell Development
- Cell Activation
- T Cell Activation
- Secretion
- Cell Differentiation
- Immune Response
- Cell Cycle
- Rna Interference
- Cell Proliferation
- Gene Silencing
- Cytokine Production
- Cell Division
PTMs
- Phosphorylation
- Biotinylation
- Farnesylation
- Palmitoylation
- Demethylation
Research Areas
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RASGRP1
bosterbio.com/bosterbio-gene-info-cards/RASGRP1
References
PMID: 9789079 by Kawasaki H., et al. A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia.
PMID: 10087292 by Bottorff D.A., et al. RasGRP, a Ras activator: mouse and human cDNA sequences and chromosomal positions.