RAS guanyl-releasing protein 2 (RASGRP2)

Functions as a calcium- and DAG-regulated nucleotide exchange factor especially activating Rap through the exchange of bound GDP for GTP. May also activates other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS.

Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils likely through inside-out integrin activation. May be the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway.