RASGRP4 Antibodies

AND RASGRP4 ELISA kits, RASGRP4 Proteins

Many biological assays use antibodies to detect RASGRP4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RASGRP4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RASGRP4 antibodies...

We validate the specificity of these antibodies to RASGRP4 by testing them on tissues known to express RASGRP4 positively and negatively. Browse below to find the RASGRP4 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RASGRP4 Infographic by Boster Bio

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RASGRP 4 (RASGRP4) (NM_170604) Human Over-expression Lysate

RASGRP 4 (RASGRP4) Human Over-expression Lysates NM_001146204

Human

$960
Cat # LS115727
20 µg, 100 µg

RASGRP4 Overview

Facts about RAS guanyl-releasing protein 4.

RASGRP4 3D structure. Source: alphafold

RAS guanyl-releasing protein 4 (RASGRP4)

Functions as a cation- and diacylglycerol (DAG)- regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. May function in mast cells differentiation.

Gene Information

Human
Gene Name:	RASGRP4
Uniprot:	Q8TDF6
Entrez:	115727

Family

Belongs to:

RASGRP family

Alternative Names

guanyl nucleotide releasing protein 4; RAS guanyl releasing protein 4; RAS guanyl-releasing protein 4

Molecular Weight

Mass (kDA):
74.882 kDA

Genomic Context


Human

Location:	19q13.2
Sequence:	19; NC_000019.10 (38409055..38426305, complement)

Tissue Specificity

Expressed by mast cells and their progenitors (at protein level). Specifically expressed in mononuclear leukocytes. Highly expressed in myeloid cells compared to lymphoid cells. Also detected in heart, skeletal muscle, spleen, liver, placenta and lung. Not detected in brain. Isoform 1 is the major isoform in normal individuals. Isoform 2 is more significantly expressed in a patient with asthma. Isoform 3 is more significantly expressed in a patient with asthma and a mastocytosis patient.

Subcellular Localizations

Cytoplasm. Cell membrane. Recruited to membranes upon activation by DAG.

Diseases

Asthma
Leukemia
Malignant Neoplasms
Inflammation
Leukemia, Myelocytic, Acute
Myeloid Leukemia
Tissue Adhesions
Neoplasms
Leukemogenesis
Cell Transformation, Neoplastic
Arthritis
Autoimmunity

Malignant Neoplasm Of Breast
Inflammatory Bowel Diseases
Leukemia, T-cell
Mastocytosis
Intestinal Diseases
Carcinoma
Allergy

Pathways

Cell Development
Gene Silencing
Cyclooxygenase Pathway
Rna Interference
Chemokinesis
Intracellular Signal Transduction
Localization
Drug Resistance
Cell Division

Cytokine Production
Chemotaxis
Translation
Cell Growth

PTMs

Phosphorylation

Research Areas

Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RASGRP4

References

PMID: 11880369 by Reuther G.W., et al. RasGRP4 is a novel Ras activator isolated from acute myeloid leukemia.

PMID: 21933395 by Hashimoto T., et al. Aberrant splicing of the hRasGRP4 transcript and decreased levels of this signaling protein in the peripheral blood mononuclear cells in a subset of patients with rheumatoid arthritis.