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Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression.
|retinoblastoma protein (RB) family|
|Sequence:||13; NC_000013.11 (48303751..48481890)|
Expressed in the retina.
Nucleus. During keratinocyte differentiation, acetylation by KAT2B/PCAF is required for nuclear localization.
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