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- Table of Contents
RBBP7 Antibodies
AND RBBP7 ELISA kits, RBBP7 Proteins
Many biological assays use antibodies to detect RBBP7, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RBBP7 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RBBP7 antibodies...
Designing a Western blot for RBBP7? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the RBBP7 Western Blot GuideRBBP7 Infographic by Boster Bio
All RBBP7 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ChIP, IP, IF, WB
$405
Cat # A03708
100ul
Cat # A03708
100ul
RBBP7 Overview
Facts about Histone-binding protein RBBP7.
Histone-binding protein RBBP7 (RBBP7)
Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that's regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism.
These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZHtwo complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. .
Gene Information
| Human | |
|---|---|
| Gene Name: | RBBP7 |
| Uniprot: | Q16576 |
| Entrez: | 5931 |
Family
| Belongs to: |
|---|
| WD repeat RBAP46/RBAP48/MSI1 family |
Alternative Names
G1/S transition control protein-binding protein RbAp46; Histone acetyltransferase type B subunit 2; histone-binding protein RBBP7; MGC138867; Nucleosome-remodeling factor subunit RBAP46; RbAp46; RBBP-7; retinoblastoma binding protein 7; Retinoblastoma-binding protein 7MGC138868; Retinoblastoma-binding protein p46; retinoblastoma-binding protein RbAp46
Molecular Weight
Mass (kDA):
47.82 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xp22.2 |
| Sequence: | X; NC_000023.11 (16844341..16870362, complement) |
Subcellular Localizations
Nucleus.
Diseases
- Retinoblastoma
- Neoplasms
- Malignant Neoplasms
- Mammary Neoplasms
- Malignant Neoplasm Of Breast
- Nephroblastoma
- Cell Transformation, Neoplastic
- Carcinoma
- Leukemia
- Neoplasm Metastasis
- Kidney Neoplasm
- Neoplasm Invasiveness
Interacting Proteins
- HDAC1
- HIST1H4A
- MTA2
- ZNF827
Pathways
- Cell Growth
- Cell Proliferation
- Cell Cycle
- Chromatin Remodeling
- Cell Migration
- Histone Deacetylation
- Localization
- Methylation
- Dna Replication
- Cell Death
- Chromatin Assembly
- Cell Adhesion
- Gene Silencing
PTMs
- Methylation
- Deacetylation
Research Areas
- Cancer
- Chromatin Research
- Growth and Development
- Stem Cell Markers
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RBBP7
bosterbio.com/bosterbio-gene-info-cards/RBBP7
References
PMID: 7503932 by Qian Y.-W., et al. Dual retinoblastoma-binding proteins with properties related to a negative regulator of ras in yeast.
PMID: 9150135 by Zhang Y., et al. Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex.