- Table of Contents
Key determinant of DSB repair pathway option, as it commits cells to HR by preventing classical non-homologous end- joining (NHEJ). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the creation of ssDNA.
|Sequence:||18; NC_000018.10 (22914121..23026486)|
Expressed in ER-positive breast cancer lines, but tends to be down-regulated ER-negative cells (at protein level).
Nucleus. Chromosome. Associates with sites of DNA damage in S/G2 phase (PubMed:10764811, PubMed:25349192). Ubiquitinated RBBP8 binds to chromatin following DNA damage (PubMed:16818604).