This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
RBPJ Antibodies
AND RBPJ ELISA kits, RBPJ Proteins
Many biological assays use antibodies to detect RBPJ, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RBPJ in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RBPJ antibodies...
Designing a Western blot for RBPJ? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the RBPJ Western Blot GuideRBPJ Infographic by Boster Bio
All RBPJ Products
Product
Figures
Specificity
Applications
Price
Anti-RBPJK/RBPJ Picoband® Antibody
1 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A00767-1
100 μg/vial
Cat # A00767-1
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, WB
$370
Cat # M00767-1
100 μg/vial
Cat # M00767-1
100 μg/vial
RBPJ Overview
Facts about Recombining binding protein suppressor of hairless.
Recombining binding protein suppressor of hairless (RBPJ)
Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins.
When associated with some NICD product of Notch proteins (Notch intracellular domain), it functions as a transcriptional activator that activates transcription of Notch target genes. Likely represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively.
Gene Information
| Human | |
|---|---|
| Gene Name: | RBPJ |
| Uniprot: | Q06330 |
| Entrez: | 3516 |
Family
| Belongs to: |
|---|
| Su(H) family |
Alternative Names
CBF1; CBF-1; CSL; H-2K binding factor-2; IGKJRB1; IGKJRB1RBPSUHCBF1; IGKJRBRBP-J kappa; immunoglobulin kappa J region recombination signal binding protein 1; J kappa-recombination signal-binding protein; KBF2; RBPJ; RBP-JK; RBPJKMGC61669; RBP-Jrecombining binding protein suppressor of hairless (Drosophila); RBPSUH; recombination signal binding protein for immunoglobulin kappa J region; recombining binding protein suppressor of hairless; Renal carcinoma antigen NY-REN-30; SUH; suppressor of hairless homolog
Molecular Weight
Mass (kDA):
55.637 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4p15.2 |
| Sequence: | 4; NC_000004.12 (26163458..26435131) |
Subcellular Localizations
Nucleus. Cytoplasm. Mainly nuclear, upon interaction with RITA/C12orf52, translocates to the cytoplasm, down-regulating the Notch signaling pathway.
Diseases
- Neoplasms
- Malignant Neoplasms
- Cell Transformation, Neoplastic
- Leukemia
- Tumor Angiogenesis
- Lymphoma
- Renal Tubular Acidosis
- Carcinoma
- Nervousness
- Hyperplasia
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
Interacting Proteins
- ATXN1
- ATXN1L
- FBXO42
- KDM1A
- NCOR2
- NOTCH1
- Notch1
- PHF8
- RITA1
- SMARCA4
Pathways
- Notch Signaling Pathway
- Cell Differentiation
- Cell Proliferation
- Cell Cycle
- Neurogenesis
- Pathogenesis
- Angiogenesis
- Localization
- Cell Fate Determination
- Cell Development
- Cell Growth
- Segmentation
- Proteolysis
PTMs
- Cleavage
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RBPJ
bosterbio.com/bosterbio-gene-info-cards/RBPJ
References
PMID: 8406481 by Amakawa R., et al. Human Jk recombination signal binding protein gene (IGKJRB): comparison with its mouse homologue.
PMID: 8016657 by Henkel T., et al. Mediation of Epstein-Barr virus EBNA2 transactivation by recombination signal-binding protein J kappa.