Regenerating islet-derived protein 3-gamma (Reg3g)

Bactericidal C-type lectin which acts exclusively against Gram-positive germs and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota.

The uncleaved form has bacteriostatic action, whereas the cleaved form has bactericidal activity against L.monocytogenes and methicillin-resistant S.