Rffl Antibodies

AND Rffl ELISA kits, Rffl Proteins

Many biological assays use antibodies to detect Rffl, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Rffl in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Rffl antibodies...

We validate the specificity of these antibodies to Rffl by testing them on tissues known to express Rffl positively and negatively. Browse below to find the Rffl antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Rffl Infographic by Boster Bio

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RFFL (NM_057178) Human Over-expression Lysate

Human

$628
Cat # LS117584
20 µg, 100 µg

Rffl Overview

Facts about E3 ubiquitin-protein ligase rififylin.

E3 ubiquitin-protein ligase rififylin (Rffl)

E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complicated.

Additionally ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate apoptosis downstream of death domain receptors. Additionally negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation.

Gene Information

Mouse
Gene Name:	Rffl
Uniprot:	Q6ZQM0
Entrez:	67338

Family

Belongs to:

No superfamily

Alternative Names

CARP-2; Caspase regulator CARP2; Caspases-8 and -10-associated RING finger protein 2; E3 ubiquitin-protein ligase rififylin; EC 6.3.2; EC 6.3.2.-; Fring; FYVE-RING finger protein Sakura; rififylin; ring finger and FYVE-like domain containing 1; RING finger and FYVE-like domain-containing protein 1; RING finger protein 189; RING finger protein 34-like; RNF189CARP2; RNF34LFRING

Molecular Weight

Mass (kDA):
42.249 kDA

Genomic Context


Mouse

Location:	11\|11 C
Sequence:	11;

Tissue Specificity

Ubiquitous. Detected in heart, brain, spleen, lung, liver, skeletal muscle, kidney, testis, thymus, whole embryo and embryonic stem cells.

Diseases

Cardiac Death
Hypertensive Disease
Fibrosis
Cardiac Arrhythmia
Pulmonary Fibrosis
Sudden Cardiac Death

Pathways

Endocytic Recycling
Cell Migration
Fibroblast Migration

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Rffl

References

PMID: 15229288 by Coumailleau F., et al. Over-expression of Rififylin, a new RING finger and FYVE-like domain- containing protein, inhibits recycling from the endocytic recycling compartment.

PMID: 19138581 by Ahmed A.U., et al. CARP2 deficiency does not alter induction of NF-kappaB by TNFalpha.