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RGS10 Antibodies
AND RGS10 ELISA kits, RGS10 Proteins
Many biological assays use antibodies to detect RGS10, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RGS10 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RGS10 antibodies...
Designing an IHC experiment for RGS10? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the RGS10 IHC GuideRGS10 Infographic by Boster Bio
All RGS10 Products
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RGS10 Overview
Facts about Regulator of G-protein signaling 10.
Regulator of G-protein signaling 10 (RGS10)
Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:8774883, PubMed:10608901, PubMed:9353196, PubMed:11443111, PubMed:18434541).
Modulates the activity of potassium channels which are activated in response to CHRM2 signaling (PubMed:11443111). Activity on GNAZ is inhibited by palmitoylation of the G-protein (PubMed:9353196).
Gene Information
| Human | |
|---|---|
| Gene Name: | RGS10 |
| Uniprot: | O43665 |
| Entrez: | 6001 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
regulator of G-protein signaling 10; regulator of G-protein signalling 10
Molecular Weight
Mass (kDA):
21.21 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q26.11 |
| Sequence: | 10; NC_000010.11 (119499817..119542719, complement) |
Subcellular Localizations
[Isoform 1]: Cytoplasm, cytosol. Nucleus. Forskolin treatment promotes phosphorylation and translocation to the nucleus.; Nucleus.
Diseases
- Inflammation
- Parkinson Disease
- Carcinoma
- Malignant Neoplasms
- Neurodegenerative Disorders
- Neoplasms
- Chimera Disorder
- Degenerative Polyarthritis
- Nervousness
- Nerve Degeneration
- Schizophrenia
- Cholangiocarcinoma
Pathways
- Localization
- Osteoclast Differentiation
- Platelet Activation
- Transport
- Cell Adhesion
- Cell Activation
- Protein Palmitoylation
- Golgi Localization
- Cell Migration
- Electron Transport
- Aging
- Immune Response
- Chondrocyte Differentiation
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RGS10
bosterbio.com/bosterbio-gene-info-cards/RGS10
References
PMID: 8774883 by Hunt T.W., et al. RGS10 is a selective activator of G alpha i GTPase activity.
PMID: 10791963 by Chatterjee T.K., et al. Cytoplasmic, nuclear, and Golgi localization of RGS proteins. Evidence for N-terminal and RGS domain sequences as intracellular targeting motifs.