Regulator of G-protein signaling 19 (RGS19)

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, together with the order G(I)a3 > G(I)a1 > G(o)a >> G(z)a/G(I)a2.

Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein. .