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RHOBTB3 Antibodies
AND RHOBTB3 ELISA kits, RHOBTB3 Proteins
Many biological assays use antibodies to detect RHOBTB3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RHOBTB3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RHOBTB3 antibodies...
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RHOBTB3 Infographic by Boster Bio
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RHOBTB3 Overview
Facts about Rho-related BTB domain-containing protein 3.
Rho-related BTB domain-containing protein 3 (RHOBTB3)
Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to allow their efficient docking and fusion at the Golgi.
Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase activity due to autoinhibition, which can be relieved by Rab9.
Gene Information
| Human | |
|---|---|
| Gene Name: | RHOBTB3 |
| Uniprot: | O94955 |
| Entrez: | 22836 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
EC 3.6.1.-; KIAA0878rho-related BTB domain-containing protein 3; Rho-related BTB domain containing 3
Molecular Weight
Mass (kDA):
69.413 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q15 |
| Sequence: | 5; NC_000005.10 (95713522..95796361) |
Tissue Specificity
Ubiquitous. Highly expressed in neural and cardiac tissues, pancreas, placenta and testis.
Subcellular Localizations
Golgi apparatus.
Diseases
- Neoplasms
- Cell Transformation, Neoplastic
- Schizophrenia
- Malignant Neoplasms
- Mycobacterium Marinum Infection
- Delusions
- Anxiety Disorders
- Malignant Neoplasm Of Breast
- Obsessive-compulsive Disorder
- Psychotic Disorders
- Epilepsy
- Mycobacterium Infections, Nontuberculous
Interacting Proteins
- BHLHE40
- RBPMS
- UBXN11
Pathways
- Transport
- Protein Transport
- Secretory Pathway
- Vesicle Transport
- Circadian Rhythm
- Cell Cycle
- Cellular Homeostasis
PTMs
- Prenylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RHOBTB3
bosterbio.com/bosterbio-gene-info-cards/RHOBTB3
References
PMID: 12426103 by Ramos S., et al. Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse.
PMID: 19490898 by Espinosa E.J., et al. RhoBTB3: a Rho GTPase-family ATPase required for endosome to Golgi transport.