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- Table of Contents
RIOK3 Antibodies
AND RIOK3 ELISA kits, RIOK3 Proteins
Many biological assays use antibodies to detect RIOK3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RIOK3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RIOK3 antibodies...
Designing an IHC experiment for RIOK3? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the RIOK3 IHC GuideRIOK3 Infographic by Boster Bio
All RIOK3 Products
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RIOK3 Overview
Facts about Serine/threonine-protein kinase RIO3.
Serine/threonine-protein kinase RIO3 (RIOK3)
Involved in regulation of type I interferon (IFN)- dependent immune response which plays a vital role in the innate immune response against DNA and RNA viruses. May act as an adapter protein critical for the recruitment of TBK1 to IRF3 (PubMed:24807708).
Phosphorylates IFIH1 on'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling (PubMed:25865883). Can inhibit CASP10 isoform 7-mediated activation of this NF-kappaB signaling pathway (PubMed:19557502).
Gene Information
| Human | |
|---|---|
| Gene Name: | RIOK3 |
| Uniprot: | O14730 |
| Entrez: | 8780 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
DKFZp779L1370; EC 2.7.11.1; homolog of the Aspergillus nidulans sudD gene product; RIO kinase 3 (yeast); RIO kinase 3; serine/threonine-protein kinase RIO3; sudD (suppressor of bimD6, Aspergillus nidulans) homolog; sudD homolog; sudD suppressor of bimD6 homolog; SUDDsudD suppressor of Aspergillus nidulans bimD6 homolog
Molecular Weight
Mass (kDA):
59.093 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 18q11.2 |
| Sequence: | 18; NC_000018.10 (23452823..23483140) |
Tissue Specificity
Widely expressed.
Subcellular Localizations
Cytoplasm.
Diseases
- Malignant Neoplasms
- Neoplasms
- Adenocarcinoma
- Pancreatic Neoplasm
- Malignant Neoplasm Of Pancreas
- Cell Invasion
- Malignant Neoplasm Of Prostate
- Neoplasm Metastasis
- Pancreatic Ductal Adenocarcinoma
- Lung Neoplasms
- Melanoma
- Metastatic Malignant Neoplasm To The Lung
Interacting Proteins
- CASP10
- IFIH1
- IRF3
- TBK1
Pathways
- Enucleation
- Methylation
- Ribosome Biogenesis
- Cell Migration
- Cell Motility
- Cell Cycle
PTMs
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RIOK3
bosterbio.com/bosterbio-gene-info-cards/RIOK3
References
PMID: 9602165 by Anaya P., et al. Isolation of the Aspergillus nidulans sudD gene and its human homologue.
PMID: 19557502 by Shan J., et al. RIOK3 interacts with caspase-10 and negatively regulates the NF- kappaB signaling pathway.