Ribonuclease H2 subunit A Antibodies

AND RNASEH2A ELISA kits, Ribonuclease H2 subunit A Proteins

Many biological assays use antibodies to detect Ribonuclease H2 subunit A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Ribonuclease H2 subunit A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Ribonuclease H2 subunit A antibodies...

We validate the specificity of these antibodies to Ribonuclease H2 subunit A by testing them on tissues known to express RNASEH2A positively and negatively. Browse below to find the RNASEH2A antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RNASEH2A Infographic by Boster Bio

All RNASEH2A Products

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Anti-RNAse H2A Antibody

Western blot analysis of RNAse H2A in HeLa cell lysate with RNAse H2A antibody at 1 μg/mL

Immunocytochemistry of RNAse H2A in HeLa cells with RNAse H2A antibody at 2 μg/mL

Immunofluorescence of RNase H2A in Hela cells with RNAse H2A antibody at 5 μg/mL

Human, Mouse, Rat

ELISA, IF, ICC, WB

$481
Cat # A07386
0.1 mg

Human RNASEH2A Recombinant Protein

3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain

SDS-PAGE, Denatured

$265
Cat # PROTO75792
Starting from 20ug

Ribonuclease H2, subunit A (RNASEH2A) (NM_006397) Human Over-expression Lysate

Human

$628
Cat # LS010535
20 µg, 100 µg

Anti-Ribonuclease H2, subunit A/RNASEH2A Antibody Picoband®

Western blot analysis of RNASEH2A using anti-RNASEH2A antibody (A07386-2)

Flow Cytometry analysis of K562 cells using anti-RNASEH2A antibody (A07386-2)

Human

ELISA, Flow Cytometry, WB

$370
Cat # A07386-2
100 µg/vial

RNASEH2A Overview

Facts about Ribonuclease H2 subunit A.

RNASEH2A 3D structure. Source: alphafold

Ribonuclease H2 subunit A (RNASEH2A)

Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the elimination of lagging- strand Okazaki fragment RNA primers during DNA replication.

Mediates the excision of single ribonucleotides from DNA:RNA duplexes. .

Gene Information

Human
Gene Name:	RNASEH2A
Uniprot:	O75792
Entrez:	10535

Family

Belongs to:

RNase HII family

Alternative Names

AGS4RNase H2 subunit A; Aicardi-Goutieres syndrome 4 protein; Aicardi-Goutieres syndrome 4; JUNB; ribonuclease H2 subunit A; ribonuclease H2, large subunit; ribonuclease H2, subunit A; Ribonuclease HI large subunit; Ribonuclease HI subunit A; ribonuclease HI, large subunit; RNase H(35); RNASEHIEC 3.1.26.4; RNHIARNase HI large subunit; RNHL

Molecular Weight

Mass (kDA):
33.395 kDA

Genomic Context


Human

Location:	19p13.13
Sequence:	19; NC_000019.10 (12802054..12813645)

Subcellular Localizations

Nucleus.

Diseases

Virus Diseases
Malignant Neoplasms
Neoplasms
Congenital Infectious Disease
Neoplasm Metastasis
Cell Transformation, Neoplastic
Malignant Neoplasm Of Breast
Congenital Neurologic Anomalies
Nervous System Disorder
Autoimmune Diseases Of The Nervous System
Chilblains
Sarcoma

Lymphocytosis
Carcinoma
Immunologic Deficiency Syndromes
Encephalopathies
Hiv Infections
Mammary Neoplasms

Pathways

Cell Proliferation
Cell Cycle
S Phase
Pathogenesis
Viral Replication

PTMs

Acetylation

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RNASEH2A

References

PMID: 9789007 by Frank P., et al. Cloning of the cDNA encoding the large subunit of human RNase HI, a homologue of the prokaryotic RNase HII.

PMID: 21177858 by Figiel M., et al. The structural and biochemical characterization of human RNase H2 complex reveals the molecular basis for substrate recognition and Aicardi-Goutieres syndrome defects.